ID   G3UD39_LOXAF            Unreviewed;       284 AA.
AC   G3UD39;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Interferon induced protein 35 {ECO:0000313|Ensembl:ENSLAFP00000025747.1};
GN   Name=IFI35 {ECO:0000313|Ensembl:ENSLAFP00000025747.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000025747.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000025747.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025747.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000025747.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025747.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the NMI family. {ECO:0000256|ARBA:ARBA00010081}.
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DR   AlphaFoldDB; G3UD39; -.
DR   STRING; 9785.ENSLAFP00000025747; -.
DR   Ensembl; ENSLAFT00000029377.1; ENSLAFP00000025747.1; ENSLAFG00000029429.1.
DR   eggNOG; ENOG502QUNN; Eukaryota.
DR   GeneTree; ENSGT00530000063686; -.
DR   HOGENOM; CLU_047262_1_1_1; -.
DR   InParanoid; G3UD39; -.
DR   OMA; GPELHDI; -.
DR   TreeFam; TF332752; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR009909; Nmi/IFP35_dom.
DR   InterPro; IPR009938; Nmi/IFP35_N.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   PANTHER; PTHR15225:SF1; INTERFERON-INDUCED 35 KDA PROTEIN; 1.
DR   PANTHER; PTHR15225; INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN; 1.
DR   Pfam; PF07334; IFP_35_N; 1.
DR   Pfam; PF07292; NID; 2.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          9..80
FT                   /note="Nmi/IFP 35"
FT                   /evidence="ECO:0000259|Pfam:PF07334"
FT   DOMAIN          81..170
FT                   /note="NID"
FT                   /evidence="ECO:0000259|Pfam:PF07292"
FT   DOMAIN          184..265
FT                   /note="NID"
FT                   /evidence="ECO:0000259|Pfam:PF07292"
SQ   SEQUENCE   284 AA;  31701 MW;  F9AB72B6510DED89 CRC64;
     LKASLMLALH TLLEEQVRLR ERLQELQQLK RDPRNAPQDK VPFPAPEFPL VFRGHTQQGR
     EVPKSLISNL RIRCPLPGGS ALITFDDPKV AEQVLQQKEH KIDMEECRLR VQVQPLELPM
     LTTIQMSSEI SSRRVLVSGF PAGLKLSEEQ LLDKVEIFFG KASIGGGDVE IRELLQGGVM
     LGFTKVAQRL CQIGQFKVPL GGQQFLLSVS PYMSGEIQKA ETWFQPVPRS VVVFNIPDVL
     DGPELHDVLE IHFQKPTRGG GEVEALRVVP PGERGLAVFT YESG
//