ID   G3UEE1_LOXAF            Unreviewed;       778 AA.
AC   G3UEE1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Intraflagellar transport 80 {ECO:0000313|Ensembl:ENSLAFP00000026199.1};
GN   Name=IFT80 {ECO:0000313|Ensembl:ENSLAFP00000026199.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026199.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000026199.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026199.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000026199.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026199.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3UEE1; -.
DR   STRING; 9785.ENSLAFP00000026199; -.
DR   Ensembl; ENSLAFT00000034559.1; ENSLAFP00000026199.1; ENSLAFG00000017096.4.
DR   eggNOG; KOG1524; Eukaryota.
DR   GeneTree; ENSGT00440000033499; -.
DR   InParanoid; G3UEE1; -.
DR   OMA; WDAQGAN; -.
DR   TreeFam; TF106117; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0030992; C:intraciliary transport particle B; IEA:Ensembl.
DR   GO; GO:0061975; P:articular cartilage development; IEA:Ensembl.
DR   GO; GO:0035630; P:bone mineralization involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR   GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR   GO; GO:0060173; P:limb development; IEA:Ensembl.
DR   GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl.
DR   GO; GO:2000051; P:negative regulation of non-canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0035567; P:non-canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR   GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0033687; P:osteoblast proliferation; IEA:Ensembl.
DR   GO; GO:0097500; P:receptor localization to non-motile cilium; IEA:Ensembl.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   Gene3D; 1.25.40.470; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR24098:SF11; INTRAFLAGELLAR TRANSPORT PROTEIN 80 HOMOLOG; 1.
DR   PANTHER; PTHR24098; OUTER SEGMENT 5; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..778
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003456376"
FT   REPEAT          102..134
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          185..217
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   778 AA;  88046 MW;  FE494ACECBC965E3 CRC64;
     LWCVLCLLNM VTHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSQI VKLPEDIYPI
     DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK SVEAHCGAVL AGRWNYEGTA
     LVTVGEDGQI KIWSKTGMLR STLAQQGRTP VYSVAWGPDS EKVLYTAGKQ LIIKPLQPSA
     RVLQWKAHDG IILKVDWNSV NDLILSAGED CKYKVWDSYG RLLYSSQPHE HPITSAAWAP
     GGELFAVGSF HTLRLCDKTG WSYALEKPNT GSIFNIAWSL DGTQIAGACG NGHVVFAHVV
     EQRWEWKNFQ VTLTKRRTMQ VRNVLNDAVD LLEFRDRVIK ASLNYAHLVV STSLQCYVFS
     TKNWNTPLIF DLKEGTVSLI QQAERHFLLV DGGGIYLYSY EGRFISSPKF PGMRTDILNA
     QTVSLSDDTI AIKDKADEKI IFLFEASTGK PLGDGKLLSH KNEILEIALD QKGLTNDRKI
     AFIDKNRDLY ITSVKRFGKE EQIIKLGTMV HTLAWSDTCN ILCGLQDTRL TVWYYPNTVY
     VDRDILPKTL YERDASEFSK NPHIVSFVGN QVTIRRADGS LIHVSISPYP AILHEYVSSS
     KWEDAVRLCR FVKEQTMWAC LAAMSVANRD MTTAEIAYAA IGEIDKVQYI NSIKNLPSKE
     SKMAHVLMFS GNIQEAEIVL LQAGLVYQAI QININLYNWE RALELAVKYK THVDTVLAYR
     QKFLETFGKQ ETNKRYLQYA EGLEIDWEKI KAKIEMEITR ERERSSNSQS SKGVGVKY
//