ID G3UM48_LOXAF Unreviewed; 837 AA.
AC G3UM48;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=SLIT and NTRK like family member 4 {ECO:0000313|Ensembl:ENSLAFP00000028907.1};
GN Name=SLITRK4 {ECO:0000313|Ensembl:ENSLAFP00000028907.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028907.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028907.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028907.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028907.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028907.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR RefSeq; XP_003420212.1; XM_003420164.2.
DR AlphaFoldDB; G3UM48; -.
DR STRING; 9785.ENSLAFP00000028907; -.
DR Ensembl; ENSLAFT00000027627.1; ENSLAFP00000028907.1; ENSLAFG00000031256.1.
DR GeneID; 100663545; -.
DR KEGG; lav:100663545; -.
DR CTD; 139065; -.
DR eggNOG; ENOG502QQXQ; Eukaryota.
DR GeneTree; ENSGT00940000160971; -.
DR HOGENOM; CLU_012706_1_0_1; -.
DR InParanoid; G3UM48; -.
DR OMA; EPSMFIH; -.
DR OrthoDB; 4114137at2759; -.
DR TreeFam; TF326378; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:InterPro.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773:SF3; SLIT AND NTRK-LIKE PROTEIN 4; 1.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..837
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003456815"
FT TRANSMEM 617..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 213..263
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 531..581
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
SQ SEQUENCE 837 AA; 94312 MW; 399DD1454822404A CRC64;
MFLWLFLILS APISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR PNQLKPPWSN
FYHLNFQNNF LNILYPNTFL NFSHAVSLQL GNNKLQNIEG GAFLGLSALK QLHLNNNELK
ILRADTFLGI ENLEYLQADY NLIKYIERGA FNKLHKLKVL ILNDNLISFL PDNIFRFASL
THLDIRGNRI QKLPYIGVLE HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA
ICETPSDLYG RLLKETNKQE LCPMGTGSDF DVRILPPSQL ENGYTTPNGH TTQTSLHRLV
TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPAPCLCKT HPSDLGLSVN
CQEKNIQSMS ELIPKPLNAK KLHVNGNGIK DVDVSDFTEF EGLDLLHLGS NQITAIKGDV
FHNLTNLRRL YLNGNQIERL YPEIFSGLHN LQYLYLEYNL IKEILAGTFD SMPNLQLLYL
NNNLLKSLPV YIFSGASLAR LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV
ALKLWLEKLN DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITL
TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT VKHEGLGNPE
CGSMQLQLRK HDHKTNKKDG LSAEAFIPQT IEQMSKSHTC GLKESETGFM FSDPPGQKVI
MRNVAEKEKD LLHVDTRKRL STIDELDELF PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR
YPEKQQDKKS KKSLIGGNHS KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKM
//
