ID G3UX33_MOUSE Unreviewed; 946 AA.
AC G3UX33;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSMUSP00000133533.3};
GN Name=Snx14 {ECO:0000313|Ensembl:ENSMUSP00000133533.3,
GN ECO:0000313|MGI:MGI:2155664};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133533.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000133533.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133533.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000133533.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133533.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; G3UX33; -.
DR SMR; G3UX33; -.
DR MaxQB; G3UX33; -.
DR ProteomicsDB; 353127; -.
DR Antibodypedia; 3006; 84 antibodies from 17 providers.
DR Ensembl; ENSMUST00000174806.9; ENSMUSP00000133533.3; ENSMUSG00000032422.19.
DR UCSC; uc009qym.2; mouse.
DR AGR; MGI:2155664; -.
DR MGI; MGI:2155664; Snx14.
DR VEuPathDB; HostDB:ENSMUSG00000032422; -.
DR GeneTree; ENSGT00950000182856; -.
DR OMA; MYVYVIS; -.
DR OrthoDB; 2877434at2759; -.
DR PhylomeDB; G3UX33; -.
DR ChiTaRS; Snx14; mouse.
DR Proteomes; UP000000589; Chromosome 9.
DR Bgee; ENSMUSG00000032422; Expressed in spermatocyte and 253 other cell types or tissues.
DR ExpressionAtlas; G3UX33; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:G3UX33,
KW ECO:0007829|MaxQB:G3UX33};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..304
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 336..468
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 570..690
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 946 AA; 110027 MW; 0B23B4DD068C1C24 CRC64;
MGSWVRTICG RLKQRLRLDV GREICRQYPL FCFLLLCLSV ASLLLNRYLH VLMIFWSFVA
GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGHS CAVCGKVKCK RHRPSLLLEN
YQPWLDLKVS SKVDASLSEV LELVLENFVY PWYRDVTDDE SFVDELRITL RFFASVLVRR
IHKVDIPSII TKKLLKAAMK HIEVIVKARQ KVKNTEYLQQ AALEEYGPEL HVALRSRRDE
LQYLRKLTEL LFPYILPPKA TDCRSLTLLI REILSGSVLL PSLDFLADPD TVNHLLIIFI
DDSPPEKATE PASPLVPFLQ KFAEPRNKKP SVLKLELKQI REQQDLLFRF MNFLKQEGAV
HVLQFCLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY CLDESIDKIR FDPFIVEEIQ
RIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH SDEYFRQLLR GAESPTRNSK
FNRGSLSLDD FRSTQKRGES FGISRIGSKI KGVFKSTTME GAVLPNYGVA EGEDDFIEEG
IVVMEDDSPV EAVSTPNTPR NLAAWKISIP YVDFFEDPSS ERKEKKERIP VFCIDVERND
RRAVGHEPEH WSVYRRYLEF YVLESKLTEF HGTFPDAQLP SKRIIGPKNY EFLKSKREEF
QEYLQKLVQH PELSNSQLLA DFLSPNGGET QFLDKILPDV NLGKIIKSVP GKLMKEKGQH
LEPFIMSFIN SCESPKPKPS RPELTILSPT SENNKKLFND LFKNNANRAE NTERKQNQNY
FMEVMTVDGV YDYLMYVGRV VFQVPDWLHH LLMGTRILFK NTLEMYTDYY LQCKLEQLFQ
EHRLVSLITL LRDAIFCENT EPRSLQDKQK GAKQTFEEMM NYIPDLIVKC IGEETKYESI
RLLFDGLQQP VLNKQLTYVL LDIVIQELFP ELNKVQKEAT SMTSWM
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