ID G3V763_RAT Unreviewed; 1840 AA.
AC G3V763;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Collagen type V alpha 1 chain {ECO:0000313|Ensembl:ENSRNOP00000012334.8};
GN Name=Col5a1 {ECO:0000313|Ensembl:ENSRNOP00000012334.8,
GN ECO:0000313|RGD:70920};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000012334.8, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000012334.8, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000012334.8,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000012334.8}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000012334.8};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_006233935.1; XM_006233873.3.
DR PeptideAtlas; G3V763; -.
DR Ensembl; ENSRNOT00000012334.8; ENSRNOP00000012334.8; ENSRNOG00000008749.8.
DR GeneID; 85490; -.
DR CTD; 1289; -.
DR RGD; 70920; Col5a1.
DR VEuPathDB; HostDB:ENSRNOG00000008749; -.
DR GeneTree; ENSGT00940000159211; -.
DR HOGENOM; CLU_001074_2_1_1; -.
DR OMA; TQGFQGK; -.
DR OrthoDB; 2970887at2759; -.
DR TreeFam; TF323987; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000008749; Expressed in esophagus and 18 other cell types or tissues.
DR ExpressionAtlas; G3V763; baseline and differential.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0005588; C:collagen type V trimer; IEA:Ensembl.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0048407; F:platelet-derived growth factor binding; IEA:Ensembl.
DR GO; GO:0043394; F:proteoglycan binding; IEA:Ensembl.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0032964; P:collagen biosynthetic process; IEA:Ensembl.
DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR GO; GO:0048592; P:eye morphogenesis; IEA:Ensembl.
DR GO; GO:0003007; P:heart morphogenesis; IEA:Ensembl.
DR GO; GO:0045112; P:integrin biosynthetic process; IEA:Ensembl.
DR GO; GO:1903225; P:negative regulation of endodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0035989; P:tendon development; IEA:Ensembl.
DR GO; GO:0035313; P:wound healing, spreading of epidermal cells; IEA:Ensembl.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000885; Fib_collagen_C.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF387; COLLAGEN ALPHA-1(V) CHAIN; 1.
DR Pfam; PF01410; COLFI; 1.
DR Pfam; PF01391; Collagen; 7.
DR Pfam; PF02210; Laminin_G_2; 1.
DR SMART; SM00038; COLFI; 1.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51461; NC1_FIB; 1.
PE 1: Evidence at protein level;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ SEQUENCE 1840 AA; 184091 MW; D9B3944FA2162812 CRC64;
MDVHTRWKAP RPGAPLLSSP LLLLLLLLWA PPPSRAAQPT DLLEMLDFHN LPSGVTKTTG
FCATRRSSKE PDVAYRVSKD AQLSMPTKQL YPESDFPEDF SILTTVKAKK GSQAFLVSVY
NEQGIQQLGL ELGRSPVFLY EDHTGKPGPE EYPLFPGINL SDGKWHRIAI SVYKKNVTLI
LDCKKKITKF LNRGDHPIID VNGIIMFGSR ILDDEIFEGD IQQLLFVSDH RAAYDYCEHY
SPDCDTAVPD TPQSQDPNPD EYYPEGEGET YYYEYPYYED PEDPGKEPAP SQKPVEAARE
TTEVPEEQTQ PPSEAPTVPE TSDTAGKEDN PGIGDYDYVP TDDYYTTSPY EDFGYGEGVE
NPDQPTNPDS GAEIPTSTSV TSNSSNPAPS PEEGKDDLGG EFTEETIKNL DENYYDPYFD
PDSDSNVSPS EIGPGMPANQ DTIYEGIGGP RGEKGQKGEP AIIEPGMLIE GPPGPEGPAG
LPGPPGTTGP TGQMGDPGER GPPGRPGLPG ADGLPGPPGT MLMLPFRFGG GGDAGSKGPM
VSAQESQAQA ILQQARLALR GPAGPMGLTG RPGPMGPPGS GGLKGEPGDM GPQGPRGVQG
PPGPTGKPGR RGRAGSDGAR GMPGQTGPKG DRGFDGLAGL PGEKGHRGDP GPSGPPGLPG
DDGERGDDGE VGPRGLPGEP GPRGLLGPKG PPGPPGPPGV TGMDGQPGPK GNVGPQGEPG
PPGQQGNPGA QGLPGPQGAI GPPGEKGPLG KPGLPGMPGA DGPPGHPGKE GPPGEKGGQG
PPGPQGPIGY PGPRGVKGAD GIRGLKGTKG EKGEDGFPGF KGDMGIKGDR GEIGPPGPRG
EDGPEGPKGR GGPNGDPGPL GPTGEKGKLG VPGLPGYPGR QGPKGSIGFP GFPGANGEKG
GRGTPGKPGP RGQRGPTGPR GERGPRGITG KPGPKGNSGG DGPAGPPGER GPNGPQGPTG
FPGPKGPPGP PGKDGLPGHP GQRGETGFQG KTGPPGPPGV VGPQGPTGET GPMGERGHPG
PPGPPGEQGL PGAAGKEGTK GDPGPAGLPG KDGPPGLRGF PGDRGLPGPV GALGLKGSEG
PPGPPGPAGS PGERGPAGAA GPIGIPGRPG PQGPPGPAGE KGVPGEKGPQ GPAGRDGLQG
PVGLPGPAGP VGPPGEDGDK GEIGEPGQKG SKGDKGEQGP PGPTGPQGPI GQPGPSGADG
EPGPRGQQGL FGQKGDEGSR GFPGPPGPVG LQGLPGPPGE KGETGDVGQM GPPGPPGPRG
PSGAPGADGP QGPPGGIGNP GAVGEKGEPG EAGEPGLPGE GGPLGPKGER GEKGEAGPSG
AAGPPGPKGP PGDDGPKGSP GPVGFPGDPG PPGEPGPAGQ DGPPGDKGDD GEPGQTGSPG
PTGEPGPSGP PGKRGPPGPA GPEGRQGEKG AKGEAGLEGP PGKTGPIGPQ GAPGKPGPDG
LRGIPGPVGE QGLPGSPGPD GPPGPMGPPG LPGLKGDSGP KGEKGHPGLI GLIGPPGEQG
EKGDRGLPGP QGSSGPKGEQ GITGPSGPLG PPGPPGLPGP PGPKGAKGSS GPTGPKGEAG
HPGLPGPPGP PGEVIQPLPI QASRTRRNID ASQLLDDGAG ESYVDYADGM EEIFGSLNSL
KLEIEQMKRP LGTQQNPART CKDLQLCHPD FPDGEYWVDP NQGCSRDSFK VYCNFTAGGS
TCVFPDKKSE GSKMARWPKE QPSTWYSQYK RGSLLSYVDA EGNPVGVVQM TFLRLLSASA
QQNITYNCYQ SVAWQDAATG SYDKAIRFLG SNDEEMSYDN NPYIRALVDG CATKKGYQKT
VLEIDTPKVE QVPIVDIMFT DFGEASQKFG FEVGPACFLG
//
