ID G3VF60_SARHA Unreviewed; 4544 AA.
AC G3VF60;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Sacsin molecular chaperone {ECO:0000313|Ensembl:ENSSHAP00000001814.2};
GN Name=SACS {ECO:0000313|Ensembl:ENSSHAP00000001814.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000001814.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000001814.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000001814.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9305.ENSSHAP00000001814; -.
DR Ensembl; ENSSHAT00000001834.2; ENSSHAP00000001814.2; ENSSHAG00000001615.2.
DR eggNOG; ENOG502QQPY; Eukaryota.
DR GeneTree; ENSGT00390000016695; -.
DR HOGENOM; CLU_000100_0_0_1; -.
DR TreeFam; TF331145; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR CDD; cd17049; Ubl_Sacsin; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR007842; HEPN_dom.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR15600; SACSIN; 1.
DR PANTHER; PTHR15600:SF42; SACSIN; 1.
DR Pfam; PF05168; HEPN; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00748; HEPN; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 3.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF81593; Nucleotidyltransferase substrate binding subunit/domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 19..64
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT DOMAIN 4310..4396
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 4255..4276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4283..4302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4407..4432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4544 AA; 518009 MW; 33F5BF75F8695F61 CRC64;
MEDRLARVTV LHGCVGCRTY EVPPPTTVGE VKELIYRDTD FPGSEQQLWH RGRELSDWIK
IEDLTYKSCD LFLNLQSKGL KGGGRFGQTT PPLVDFLKDI LRRYPEGGQI LKELIQNAED
AGATEVKFLY DETQYGKETL WSKDMEQYQG SALYVYNNAV FTPEDWHGIQ EIARSRKKDD
PLKVGRFGIG FNSVYHITDV PCIFSGDQIG MLDPHQTLFG PHESGQCWNL KDDSKEISEF
SDQFAPFIGV FGSTKETFLN GNFPGTFFRF PLRLQPSQLS NNLYNKQKIL ELFDSFKADA
DTVLLFLKSV QDVSLHVREA DGTEKLIFRV TASENKALKH ERPNSIKILG TAISNYCKKV
PSNSITCVTY HINIVLEDES TKDAQKTSWL VCNSVGGRGI CNELDCLADD LKFVPTIGIA
MSLSSSEEQT GAIADFSGKA FCFLPLPPGE ESKTGLPVHV SGFFGLTDNR RSIKWRELDQ
WRDPAALWNE LLIVNVVPKA YATLVLDSIK RLETEKNSDF PLSVEIIYKL WPELSRVKVH
WQPIIEPLFK ELFQNAVIYS ISNHWIKLEQ AYFSELDESL EYTKAVLNYL QSSGKQIVKV
PTNISNAVQL TASSAKPVKK VTPALVRQVL KKHGHSGTAA EKLHLLEFVL SDAAYHELLG
LDLLPLQNGN FIPFSSSVSD QDVIYITSED YPRSLFPGLE GRIILDDLKP QILASLKEAA
QTRAQQLLWG YSGRPCTQLQ LLNSERFARL IKEVMNAFWP GRELVVQWHP FAEDSHHPSV
VWLKMVWKNL YIHFSEDLSL FDEMPLIPKT ILEKSQTFME LIRLRIPSPV ILDDESEAQL
PEFLADIVQN LGGIVLKKLD PSIQHPLIKK YVHAPLPSAV LQIMEKMSLQ KLCNQVASLL
PTHKDALRKF LASLTDINEK EKRIIQELTI FKRINHSSSQ GISSFTKLKG CKVLHHTAKL
PPDLRLSIPV IDNSDEATIR LANMLKVEQL KSTGCLKFIL KDIENGFYSH EETTQLMLWI
LEHLSSLKNE NPRVIDWVMP LKFIQISQGH IVSANELFDS DISILQDLFY AEEEISFPPS
IFTSSLDILH SLRQIGLKNE TSLKEKDIIQ VAKKIEELQV SSSPNLDALL KKAKTLLMIL
NKNHTLLQSP EAKATLKKIK WVPTCKERPP NYPGSLIWKG DLCNLCSPPE MCDVSHATLV
GSSVPLVESI HANLEKALGI FTKPSINAVL KHFKIVVDWH SSKTFSDEDY YQFQHILLEI
YGFMHDHLDE GKEAFKALKF PWVWTGKKFC PLAQAVIKPI HDLELQPYLH SVPKTMAKFH
QLFKVCGSIE ELTSDHISMV IQKVYLKSDQ ELSEEESKQN LHLMLNIIRW LYSSQIPASP
NTPVPIHYSK NPLKLMMKPI HECCYCDIKV DDLNDLLEDS VEPIILVHED IPMKTAEWLK
VPCLSTRLIN PENMGFEQSG QREPLTVRIK NILEEYPSVS DIFKELLQNA DDADATECNF
MIDMRRNMDI RENLLDPGMA ACHGPALWSY NNSEFSDSDF INITRLGESL KRGEVDKVGK
FGLGFNSVYH ITDIPIIMSR EFMIMFDPNI NHISKHIKDK SNPGIKINWS KQQKRLRKFP
NQFKPFIDVF GCQLPLTVEA PYSYKGTLFR LSFRTQQEAK QSEISSTCYN TADIYSLVDE
FSLCGHRLIL FTQNVNTMFL KYLKIEETNP GLAQDIIIIK KNMCSSKVLN VPIVSVLKEA
AKLMKTCSSS NKKLSMDIPK SSCILQITVE EFRHVFRRIA DLQSPLFRGP DDDPATLFEM
AKSGQAKRPS EELPQKTVDS TTWLICTCMD VGEALKFSLN ENGRRLGLVP CGAVGVLFSE
AQDQKWIVKQ HIGEIFCYLP LRIKTGLPIH INGCFAVTSN RKEIWKTDTK GRWNNIFMRH
VIVKAYLEAL SVLRELAISG ELIDYTYYAV WPDPDLVHDD FSVICQGFYE DIAHGKGKDV
SRVFSDGSMW VSMKNVRFLD DCILKRSDIG PAAFKIFLKY LKKTGSKNLC AVELPSSVKL
GFEEAGCKQI LLENTFSERQ FFSEVFFPNI QEIEAELRDP LMYFLLNEKV EEFSGILRVT
PCVPCSLEGH PLVLPSRLIH PEGRVAKLFE TKDGRFPYGS TQDYLNPIIL IKLVQLGMAK
DDILWDDMLE RAESVAEINK RDHAAACLRS SILLNLIDEK LKIRDPRAKD FSSKYQKIPF
LPFLTKPAGF SLEWKGSSFK PETMFAATDL YTAEYQDIVC LLQPILNENS HSFKGCGSMS
LAVKEFLGLL KKPTVDLVIN QLKEVAKSLD GITLYQENIT NACYKYLHEA MLQNETTKTS
IIEQLKTYNF ILVENAYVEP DKVSFHLNFD AAPYLYQLPN KYKNNFRELF ESIGVRSSFT
VEDFAFVLES INQERGTKQI TEANFQLCRR IVSEGIWSLI REKNQEFCEK KYGKILLPDT
NLALLPAESL CYNDCPWIKV KDTSVKYCHA DIPREVAVKL GAVPKRHKAL ERYASNICFT
TLGTEFGQKE KLTSRIKSIL NAYPSEKEML KELLQNADDA KATEICFVFD PRQHPVDRIF
DDKWAPLQGP ALCVYNNQPF TEDDVRGIQN LGKGTKEGNP CKTGQYGIGF NSVYHITDCP
SFISGNDILC IFDPHARYAP GATSVSPGRM FRDLDSDFRT QFSDVLDLYL GDHFKLDNCT
MFRFPLRNGE MAKVSEISSV PSSDRMVQNL LDKLRSDGAE LLMFLNHMEK ISICEIEKAT
GALNVLYSVK GKITDGDRLK RKQFHASVID SVTKKKQLKD IPVQQITYTM DTEDSEGNLT
TWLICNRSGF SSMDKVSKSV ISAHKNQDIT LFPRGGVAAC ITHNYKKPHR AFCFLPLSLE
TGLPFHVNGH FALDSARRNL WRDDNGVGVR SDWNNSLMTA LIAPAYVELL IQLKKRYFPG
TDPTMSILQN TAIHVVKDTL KKFLSFFPVN RLDLQPDLYC LVKALYTCIH EDQKRLLPVV
RAPNIDGSDL HSAVIITWVN MSTSNKTKPF FDNLLQDELQ HLKNVEYNIT TRKTIAENVY
RLKHLLLEIG FNLIYNCDET ANLYHCLIDA EIPASYVTPA DVRSFLMTFS SPDTNCHIGK
LPCRLQQTNL KLFHSLKLLV DYCFKDAEEN EMVVEGLPLL ITVDSVLQIF DAKRPKFLTT
YHELIPSRKD LFMNTLYLRY SNILLTSKVA KVFDITSFAD LLSSVLPREY KTKSCTKWKE
NFASESWLKN TWNFISESVN VKEDQEEIKP TFDIVVDTLK DWALLPGTKF TVSASHLVVP
EGDVLLPLSL MHIAVFPNAQ SDKVFHALMK AGCIQLALNK ICSKDNVIVP LLSAHTANID
NPTSILKAIH YMVQTSTFRT EKLAEHDFEA LLMYFNCNLS HLMSQDDIKI LKSLPCYKSI
SGRYMSIAKF GACYVLTKTI PPAEVEKWTL SSSSAFLEEK IHLKELYEVL GCVPVDDLEV
YLKHLLPKIE NLSYDAKLEH LIYLKNRLSS IEESSEIKEQ LFEKLESLLI IHDASNRLKS
AKHFYDRTVK VFEVMLPEKL FIPKDFFKKL EQLTKPKNQT SFLTSWVMFL RNMGLKYILS
QQQLLQFAKE VSMRANTENW SKETLQNTVD VLLYHIFQER TDLLSGNFLK ELSLIPFLCP
ERAPAEFIRF HPQYQEVNGT LPLIRFNGAQ VNPKFKQSDV LQLLWTSCPI LPEKATPLSI
KEQEGSTLGP QEQLEQVLTM LNVNLDPPLD KVIHNCRNIC NITTLDEEMV KTRAKVLRSI
YEFLSAEKKE FRFQLRGVAF VMVEDGWKLL KPEEVVINLE YESDFKPYLY KLPLELGTFH
QLFKHLGTED VISTKQYVEV LSRIFKNSEG KQLDPNEMRT VKRVVSGLFK SLQNDSVKVR
NDLENVRDLA LYLPSQDGRL VKSSILVFDD APHYKSRIQG HIGVQMLVDL SQCYLGKDHG
FHTKLIMLFP QKLRPRLLSS ILEEQLDEET PKICQFGALC SLQGRLQLLL SSEQFITGLI
RIMKHENDNA FLANEEKAIR LCKALREGLK VSCFEKLQTT LRVKGFNPIP HSKSETFAFL
KRYGNAVILL YIQHSDSKDI NFLLALAMTL KSATDNLISD TSYLIAMLGC NDIYRISEKL
DSLGVKYDSS EPSKLELPMP GTPIPAEIHY TLLMDPMNVF YPGEYVGYLV DAEGGDIYGS
YQPTYTYAII VQEVEREDAD NSSFLGKIYQ IDIGYSEYKI VSSLDLYKFS RPDESSQIRD
SAPSTPTSPT EFPVPGLRSI PPIFSGKEGH KTSSKHQSPK KIKVNSLPEI LREVTSVVEQ
AWKLPESERK KIIRRLYLKW HPDKNPENHD MANEVFKHLQ NEISRLEKQA FIDQNTDRTS
RRTFSTASRF QSDKYSFQRF YTSWNQEATS HKSERQQQNK EKGPSSTGQS YSQRFFVPPT
FKTVGNPVEA RRWLRQARAN FSAARNDLHK NANEWVCFKC YLSTKLALIA ADYAVRGKSD
KDVKPTALAQ KIEEYSQQLE GLTNDVHTLE AYGVDSLKTR IKRR
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