ID G3VFV2_SARHA Unreviewed; 250 AA.
AC G3VFV2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=WAP four-disulfide core domain 8 {ECO:0008006|Google:ProtNLM};
GN Name=LOC111718807 {ECO:0000313|Ensembl:ENSSHAP00000002056.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002056.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000002056.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000002056.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3VFV2; -.
DR Ensembl; ENSSHAT00000002079.2; ENSSHAP00000002056.2; ENSSHAG00000001828.2.
DR eggNOG; KOG4295; Eukaryota.
DR GeneTree; ENSGT00940000162037; -.
DR HOGENOM; CLU_092095_0_0_1; -.
DR InParanoid; G3VFV2; -.
DR TreeFam; TF335948; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00109; Kunitz-type; 1.
DR Gene3D; 4.10.75.10; Elafin-like; 3.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008197; WAP_dom.
DR InterPro; IPR042931; WFDC8/12/15B-like.
DR PANTHER; PTHR47769; WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8; 1.
DR PANTHER; PTHR47769:SF1; WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00095; WAP; 3.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SMART; SM00217; WAP; 3.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF57256; Elafin-like; 3.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51390; WAP; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 54..101
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 105..155
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 157..204
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 205..250
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
SQ SEQUENCE 250 AA; 28609 MW; B4D2C908D5A98944 CRC64;
MFFWILQTMT AGTRGNRAKS PHHTWFWKRV INIFLILSLS LKWTHGFIHK NFSVPRRSGI
CPTQNITCDL VEKDQCVMDF DCKSPMKCCK YNCGKKCLKP YIEICLLIPE VGDCENFSLR
WFYSTKARAC KHFFYSGCDG NVNNFPTKKI CEQSCAGTVR PGKCPPFPFK GFKNCSVPCH
KDQQCQKPYK CCASSCGFVC TPPWKVKPWD CPPQPSTCMV IQKPLCQNDE ECGTDEKCCT
NCGFTCIKRN
//
