ID G3VIJ9_SARHA Unreviewed; 188 AA.
AC G3VIJ9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Adrenal ferredoxin {ECO:0000256|ARBA:ARBA00042934};
DE AltName: Full=Ferredoxin-1 {ECO:0000256|ARBA:ARBA00041333};
GN Name=FDX1 {ECO:0000313|Ensembl:ENSSHAP00000003003.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000003003.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000003003.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000003003.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- SUBUNIT: Interacts with CYP11A1. {ECO:0000256|ARBA:ARBA00038759}.
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DR RefSeq; XP_003766896.1; XM_003766848.2.
DR AlphaFoldDB; G3VIJ9; -.
DR STRING; 9305.ENSSHAP00000003003; -.
DR Ensembl; ENSSHAT00000003038.2; ENSSHAP00000003003.1; ENSSHAG00000002662.2.
DR GeneID; 100913253; -.
DR KEGG; shr:100913253; -.
DR CTD; 2230; -.
DR eggNOG; KOG3309; Eukaryota.
DR GeneTree; ENSGT00940000156916; -.
DR HOGENOM; CLU_082632_2_1_1; -.
DR InParanoid; G3VIJ9; -.
DR OMA; TCDGEME; -.
DR OrthoDB; 36668at2759; -.
DR TreeFam; TF319845; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:Ensembl.
DR GO; GO:0009055; F:electron transfer activity; IEA:Ensembl.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:1904322; P:cellular response to forskolin; IEA:Ensembl.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl.
DR GO; GO:0140647; P:P450-containing electron transport chain; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR001055; Adrenodoxin.
DR InterPro; IPR018298; Adrenodoxin_Fe-S_BS.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR PANTHER; PTHR23426:SF26; ADRENODOXIN, MITOCHONDRIAL; 1.
DR PANTHER; PTHR23426; FERREDOXIN/ADRENODOXIN; 1.
DR Pfam; PF00111; Fer2; 1.
DR PRINTS; PR00355; ADRENODOXIN.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00814; ADX; 1.
PE 4: Predicted;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Iron {ECO:0000256|ARBA:ARBA00023014};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Steroidogenesis {ECO:0000256|ARBA:ARBA00023250};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..188
FT /note="Adrenal ferredoxin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003457596"
FT DOMAIN 71..175
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
SQ SEQUENCE 188 AA; 19868 MW; 3972B14F2F1EB2F6 CRC64;
MAALGSTRLL LAASAAFGAA SRRCFLLAGA RAGAGRPGWH GLPKQGSAAC SGASRCFSLS
APSRRSSEDK ITIHFINRDG DKLTTQGKVG DTLLDVVVNN NLDIDGFGAC EGTLACSTCH
LVFEDHIFEK LEAITDEEND MLDLAYGLTD TSRLGCQICL TKSMNNMTVR VPEAVADARQ
SIDLGKNS
//
