ID G3VPY0_SARHA Unreviewed; 2040 AA.
AC G3VPY0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSSHAP00000005235.2};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSSHAP00000005235.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000005235.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000005235.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000005235.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 9305.ENSSHAP00000005235; -.
DR Ensembl; ENSSHAT00000005287.2; ENSSHAP00000005235.2; ENSSHAG00000004581.2.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000155279; -.
DR HOGENOM; CLU_000134_29_2_1; -.
DR TreeFam; TF351263; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 80..112
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 113..145
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 146..178
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 241..273
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 274..306
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 307..339
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 340..372
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 373..405
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 406..438
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 439..471
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 472..504
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 505..537
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 538..570
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 571..603
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 604..636
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 637..669
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 670..702
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 703..735
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 736..768
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 769..801
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 995..1150
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1152..1298
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1478..1562
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 2040 AA; 226034 MW; 895084C78DB57155 CRC64;
MGNAALCQSC HTEKSIKAQG NMQELDRTPD YYGYNCEDVR ESKALSDSNA SFLRAARAGN
LDKVVEYLKG GIDINTCNQN GLNALHLAAK EGHVGLVQEL LERGSAVDSA TKKGNTALHI
ASLAGQAEVV KVLVKEGANI NAQSQNGFTP LYMAAQENHL DVVKYLLENG ANQSTATEDG
FTPLAVALQQ GHNQAVAILL ENDTKGKVRL PALHIAARKD DTKSAALLLQ NDHNADVQSK
SGFTPLHIAA HYGNVNVATL LLNRGAAVDF TARNGITPLH VASKRGNTNM VKLLLDRGGQ
IDAKTRDGLT PLHCAARSGH DQVVELLLER GAPLLARTKN GLSPLHMAAQ GDHVECVKHL
LQHKAPVDDV TLDYLTALHV AAHCGHYRVT KLLLDKRANP NARALNGFTP LHIACKKNRI
KVMELLVKYG ASIQAITESG LTPIHVAAFM GHLNIVLLLL QNGASPDVTN IRGETALHMA
ARAGQVEVVR CLLRNGALVD ARAREEQTPL HIASRLGKTE IVQLLLQHMA HPDAATKNGY
TPLHISAREG QVDVASVLLE AGAAHSLATK KGFTPLHVAA KYGSLDVAKL LFQRRASPDS
AGKNGLTPLH VAAHYDNQKV ALLLLEKGAS PHATAKNGYT PLHIAAKKNQ MQIAMTLLNY
GAETSIVTKQ GVTPLHLASQ EGHTDMVTLL LDKGSNIHMS TKSGLTSLHL AAQEDKVNVA
EILTKHGANK DAQTKLGYTP LIVACHYGNV KMVNFLLKQG ANVNAKTKNG YTPLHQAAQQ
GHTHIINVLL QHGAKPNAIT TNGNTALAIA KRLGYISVVD TLKVVTEEVT TTTTTVTEKH
KLNVPETMTE VLDVSDEEAL KQFGGHFSDG EALSDSGEDT MTGDGGEYLR PEDLKELGDD
SLPSSQFLDG MSYLRYSLEG GRSDSLRSFS SDRSHTLSHA SYLRDSTMID ETVVIPSHQV
STLAKEAERT SYRLSWGTDH LDNVALSSSP IHSGFLVSFM VDARGGAMRG CRHNGLRIII
PPRKCTAPTR VTCRLVKRHR LATMPPMVEG EGLASRLIEV GPSGAQFLGP VIVEIPHFAA
LRGKERELVI LRSENGDSWK EHYCEYTEDE LNEILNGMDE VLDNPEDLEK KRICRIITRD
FPQYFAVVSR IKQDSNLIGP EGGVLSSTVV SQVQAVFPEG ALTKRIRVGL QAQPMHSELI
RKILGNKATF SPIVTLEPRR RKFHKPITMT IPVPKISSDC MLNGFGGDTP TLRLLCSITG
GTTPAQWEDI TGTTPLTFVN ECVSFTTNVS ARFWLIDCRQ IQESVTFASQ VYREIICVPY
MAKFVVFAKS QDPIEARLRC FCMTDDKVDK TLEQQENFAE VARSRDVEVL EGKPIYVDCF
GNLVPLTKSG QHHIFSFFAF KENRLPLFVK VRDTTQEPCG RLSFMKEPKS SRGLVHQAIC
NLNITLPLYT KESDSDQEQE EEIDMTSEKN LQNDQEHIEE RLAHIADHLG FSWTELAREL
DFTEEQIHQI RIENPNSLQD QSHALLKYWL ERDGKHATDK SLTECLTKIN RMDIVHLMET
CIMEPLQERT SRTYAEIEQT IALDHSEGFS VLQEEMCTPP HKKREQAVSK EHESFSDHPP
IVSEEDISVG YSSFQDSISK TEGELTVEEL TQQIHKERMQ TEFSGKLEDL KEVSPIDHQQ
EYFVTTPGTE QEEPRKVVQL TGFLLKTPEE ITGTFEEERL YIPTPAPNDQ GESPIVQEPE
EFLLNKDESS PRRSSLVIIE SAEDQAQKLE KFEEESFEKE LTKELGELND SSDEDAMVTT
RVVHRRVIIQ GNEMPDIPSE TVTEEEYIDE HGHTVVKKVT RKVIRRYLSP EGIEKEVTTC
GTLQEPVIIE EGDGYSKVIK RVVLKSNSEQ SEVTFSEPNV SQFQSEPVEG RKVSKVVKTT
MVHGERMEKH LGDASLATDL PSAKDDFEEA LSYAGSHGKV HLPSLVENEI MKEDGSVIKR
TTMNKAERQK RTVVKDQHEK HIHLEQMEDT PEALKPDDLQ HDLQQFLRYF CREDWKHEAK
//
