ID G3VRN4_SARHA Unreviewed; 485 AA.
AC G3VRN4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Selenocysteine lyase {ECO:0000256|ARBA:ARBA00040554};
DE EC=4.4.1.16 {ECO:0000256|ARBA:ARBA00039054};
GN Name=SCLY {ECO:0000313|Ensembl:ENSSHAP00000005839.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000005839.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000005839.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000005839.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the decomposition of L-selenocysteine to L-alanine
CC and elemental selenium. {ECO:0000256|ARBA:ARBA00037407}.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR AlphaFoldDB; G3VRN4; -.
DR STRING; 9305.ENSSHAP00000005839; -.
DR Ensembl; ENSSHAT00000005893.2; ENSSHAP00000005839.2; ENSSHAG00000005094.2.
DR eggNOG; KOG1549; Eukaryota.
DR GeneTree; ENSGT00940000157773; -.
DR HOGENOM; CLU_003433_0_0_1; -.
DR InParanoid; G3VRN4; -.
DR TreeFam; TF313550; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR Gene3D; 1.10.260.50; -; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11601:SF62; SELENOCYSTEINE LYASE; 1.
DR Pfam; PF00266; Aminotran_5; 2.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 72..154
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT DOMAIN 174..467
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT REGION 25..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 51993 MW; 780887B7C9C02879 CRC64;
MGAPLLSNCQ PRLGWIGRGR VEGLPGGARP ARHQRAGMEG AAALPAGRTG SGSPPVAGEN
GGGETCPRER KVYMDYNATT PLEPEVMQVV TEAMQEAWGN PSSPYLAGRK AKDMINVARE
NLAKMVGGKS QDIIFTSGGT EANNLVIHST MKLFQESQRS KGAWLAEQQA GLVSRAKPHF
ITCTVEHDSI RLPLEQLEKE GMAEVSFVPV SKLSGQAEAD DVLAAVRPTT RLVTIMLANN
ETGVIMPISE ISRRIKALNQ TRAASGLPAV LVHTDAAQAL GKRRVDVQDL GVDYLTIVGH
KFYGPRIGAL YVRGLGVVTP LNPMLFGGGQ EGNFRPGTEN TPMIAGLGKA AELVNKNCDI
YEAHMRKMRD YLEDRLQAVF DKRIHLNSLF PGSERLANTC NFSISGPQLK GRLVLSHCRT
LLASVGAACH QGDLPSPILL SCGIAPAVAR NAVRLSVGRT TTKEEVDLAV EDLKQAVAQL
EKSLS
//