ID G3VVB2_SARHA Unreviewed; 630 AA.
AC G3VVB2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Aspartyl-tRNA synthetase 2, mitochondrial {ECO:0000313|Ensembl:ENSSHAP00000007117.2};
GN Name=DARS2 {ECO:0000313|Ensembl:ENSSHAP00000007117.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000007117.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000007117.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000007117.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Type 1 subfamily. {ECO:0000256|ARBA:ARBA00006303}.
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DR AlphaFoldDB; G3VVB2; -.
DR STRING; 9305.ENSSHAP00000007117; -.
DR Ensembl; ENSSHAT00000007179.2; ENSSHAP00000007117.2; ENSSHAG00000031364.1.
DR eggNOG; KOG2411; Eukaryota.
DR GeneTree; ENSGT01030000234618; -.
DR HOGENOM; CLU_014330_3_1_1; -.
DR OrthoDB; 1046261at2759; -.
DR TreeFam; TF314827; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR CDD; cd04317; EcAspRS_like_N; 1.
DR Gene3D; 3.30.1360.30; GAD-like domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00044; Asp_tRNA_synth_type1; 1.
DR InterPro; IPR004364; Aa-tRNA-synt_II.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004524; Asp-tRNA-ligase_1.
DR InterPro; IPR047089; Asp-tRNA-ligase_1_N.
DR InterPro; IPR002312; Asp/Asn-tRNA-synth_IIb.
DR InterPro; IPR004115; GAD-like_sf.
DR InterPro; IPR029351; GAD_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR NCBIfam; TIGR00459; aspS_bact; 1.
DR PANTHER; PTHR22594:SF5; ASPARTATE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22594; ASPARTYL/LYSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF02938; GAD; 1.
DR Pfam; PF00152; tRNA-synt_2; 2.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR PRINTS; PR01042; TRNASYNTHASP.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF55261; GAD domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..630
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029549352"
FT DOMAIN 186..567
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 630 AA; 71405 MW; F21C721B42547E3F CRC64;
MPFPWGLCLM HRSWARPLRG TAPLLGSPAR RLTLSAPRRI SDFNSFVVRT NTCGELRSSH
LGQDVTLCGW IQYRRQSLFL ILRDFHGLIQ VVIPQDESAT SVKKVLCEAP IESVVQVTGT
VISRPPGQEN PKMPTGEIEI KVKTAELLNP CKKLPFEIKD FIKKTEALRM KYRYLDLRSS
QMQYNLRLRS QIVMKMREYL CNLHGFVDIE TPTLFKKTPG GAKEFVVPSR EPGKFYSLPQ
SPQQFKQLLM VGGFDRYFQI ARCYRDEGSK PERQPEFTQV DIEMSFVDQA GIQKLIEGLL
QYSWPTDKTP LTIPFPSMTY TEALNLYGTD KPDTRFGMKI VDVSDVFRNA EIEFLQDVLK
EPQGTIKAIC IPGGAKYLRS KDFETIKQFA VDHFNQEVSP VFLKTSGSGK SPLTKLLKEE
EKSTLIRLMR VQEEDMLLLA AGEHKKVCSV LGKLRLECAD LLEARGVELR DPALFHFLWV
VEFPLFLPKE EDPTELESAH HPFTAPHPND GHLLYTEPEK EDVKMLSHLL QALDFGAPPH
GGIALGLDRL VCLITGAPSI RDVIAFPKSF RGHDLMSNAP DYMSPEEIEP YHIQVKSPEV
TDRKDVKSVI SETESSQELV FPSLAKAENP
//
