ID G3VYA5_SARHA Unreviewed; 1212 AA.
AC G3VYA5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN Name=SMC1B {ECO:0000313|Ensembl:ENSSHAP00000008160.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000008160.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000008160.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000008160.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC1 subfamily.
CC {ECO:0000256|ARBA:ARBA00005597}.
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DR AlphaFoldDB; G3VYA5; -.
DR STRING; 9305.ENSSHAP00000008160; -.
DR Ensembl; ENSSHAT00000008227.2; ENSSHAP00000008160.2; ENSSHAG00000007070.2.
DR eggNOG; KOG0018; Eukaryota.
DR GeneTree; ENSGT00940000157633; -.
DR HOGENOM; CLU_001042_0_2_1; -.
DR InParanoid; G3VYA5; -.
DR TreeFam; TF101156; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR GO; GO:0030893; C:meiotic cohesin complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:Ensembl.
DR CDD; cd03275; ABC_SMC1_euk; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR028468; Smc1_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR18937:SF147; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 1B; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 2.
DR PIRSF; PIRSF005719; SMC; 2.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 469..585
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 219..432
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 711..772
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 819..853
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1212 AA; 139372 MW; 519385DADA6F2341 CRC64;
MGRLDRLLVE NFKSGRHQVP RPFTTSTIVG PNGSGKSNVM DALSFVMGEK PNNLRVKTVQ
ELIHGAHVGR PVAASASVKA VYVEEDGGEK TFTRIIRGAW GPPPPSLLLV GNHANIIDHV
NKNYENCMIK SVSAKNPLGI SGLFLNIVTH NNSLLWFCPN QADRYQVLLE ELKEKKIQLQ
LFQLYHNEKK IHFLTGELDE MNRQLALTKD SVSADENIVK NKKKDLGKLT RELQQMEKEM
KALEAVLNQK RPQYIKAKEN TSHHLKKLEM AKKSIKVSEK QCTKQEDDIQ ALEKELQELD
GSWKNFEKQI EEEKLRRGRD IELEASQLDQ YKELKEQVIK KVATMTQQLE KLQWEQRADE
ERQAFGDRRR TEVQGNLKQI KEQIEDHNKR IEKLEEYTNA CIDCLKEKTQ QEEALVKEIE
ESKVRMVKVN EELSFIRMEL QDARIDHHEG KRQQKKVEIL ECLKRLYPES VFGRLLDLCH
PIHKKYQLAV TKLFGRYLTA IVVVSEKIAR DCIRFLKEER AEAETFLALD NLDIKPLNER
LREIKGSKMV IDVVQTQLPQ LKKVIQFVCG NGLVCETVEE ARHVAFGGSE RLKTVALDGT
LFLKSGVISG GSSDLKIKAK CWDDKELTKM KERRDQLTSE LKDMMKIRHK ETDLRQIQSL
LQGTHTRLKY SQNELEMIKK KQLAAFHKEQ SQLQSELLNI ESQYTMLSDG IKERAQKITD
FQERIDKVED EIFHDFCEEI GVENIREYEN QHVKQQQEID KKRLEFEKLK TRLNVQLEYS
HNQLKKKMSK VSALKEAVLK DTSDIESLKE VEESCLQVVD DLMAQRQQLK DRCAAKNTDI
EQVQGQVEEA RKKLLRAFCR EVGKMQKETV AVQTALEQQR LERHNILLAC KVQDIEVVLL
SGSLDDIIHV VGTEPESTQS TIAIYEQEGT LQIDYSSLRG DLKDLESDKE IKAQLGLLQQ
QLATQEDILL KTTAPNLRAQ QNLQTVRNKF QESIDAFEAS RKEARVCRQE FEQVKKRRYD
LFSQCFEHVS LSVDYIYKKL CRNSGAQAFL SPENPEEPYL EGVSYNCVAP GKRFMPMENL
SGGEKCVAAL ALLFAVHSFR PAPFFVLDEV DAALDNTNID KVSSYMREQT REHFQMIVIS
LKEEFYSKAD ALVGIYPEQG DCMFSRVLTL DLSVYPDSNN REHRGRHPPH FGCPGEINLV
AELGSAVAPS VK
//
