ID G3W0E1_SARHA Unreviewed; 733 AA.
AC G3W0E1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=MTSS I-BAR domain containing 1 {ECO:0000313|Ensembl:ENSSHAP00000008896.2};
GN Name=MTSS1 {ECO:0000313|Ensembl:ENSSHAP00000008896.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000008896.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000008896.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000008896.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3W0E1; -.
DR STRING; 9305.ENSSHAP00000008896; -.
DR Ensembl; ENSSHAT00000008969.2; ENSSHAP00000008896.2; ENSSHAG00000031768.1.
DR eggNOG; ENOG502QRG4; Eukaryota.
DR GeneTree; ENSGT00950000183156; -.
DR HOGENOM; CLU_1312679_0_0_1; -.
DR TreeFam; TF320619; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR CDD; cd22060; WH2_MTSS1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR030127; MTSS1/MTSS2.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR15708; ACTIN BUNDLING/MISSING IN METASTASIS-RELATED; 1.
DR PANTHER; PTHR15708:SF10; PROTEIN MTSS 1; 1.
DR Pfam; PF08397; IMD; 1.
DR Pfam; PF02205; WH2; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51338; IMD; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 46..230
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT DOMAIN 705..722
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 235..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..608
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 79674 MW; 4B79A5E430BDDC73 CRC64;
MQLSGCGKNQ TQKQTCHQVH RPRFLPPAPP CLLLAWPVVT RRAAAGGTRE IGSALTRMCM
RHRSIETKLR QFSSALIDCL INPLQEQMEE WKKVANQLDK DHAKEYKKAR QEIKKKSSDT
LKLQKKAKKA ETVGRGDIQP QLDSALQDVN DKYLLLEETE KQAVRKALIE ERGRFCAFIS
MLRPVIEEEI SMLGEITHLQ TISEDLKSLT MDPHKLPSSS EQVILDLKGS DYSWSYQTPP
SSPSTTMSRK SSVCSSLNSV NSSDSRSSGS HSHSPSSHYR YRSSNLPQQA PMRLSSVSSH
DSGFISQDAF QSKSPSPMPP ETPNQLSNGF YHYSLPSESH VASVGAGLYP HCLPVSRLCP
RAASALLPDY VHYYTIGPGM LPSSKIPSWK DWAKPGPYDQ PVANTLQRRK EKREPDSNGG
PPGLPAAPAE EAQRPRSMTV SAATRPGEEM EACEELALAL TRGLQLDPQR SSRDSLQCSS
GYSTQTTTPC CSEDTIPSQV SDYDYFSVSG DQETEQQEFD KSSTIPRNSD ISQSYRRMFQ
AKRPASTAGL PTTLGPVIVT PGVATIRRTP STKPSVRRGT IGAGPIPIKT PVIPVKTPTV
PDLPGMLPSP QGGPEGHGEH SPESPSAGET AQGGASGPAS MWSGQASVNP PLPGPKPSVP
EEQRQSAPET EEEETEGDHS SATSSPGQTP ECSNPGDLSP GDTLQGEDML NAIRRGVKLK
KTLTNDRSAP RLS
//
