ID G3W5P8_SARHA Unreviewed; 1604 AA.
AC G3W5P8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 3 {ECO:0000313|Ensembl:ENSSHAP00000010753.2};
GN Name=TRPM3 {ECO:0000313|Ensembl:ENSSHAP00000010753.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000010753.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000010753.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000010753.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 9305.ENSSHAP00000010753; -.
DR Ensembl; ENSSHAT00000010847.2; ENSSHAP00000010753.2; ENSSHAG00000009271.2.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000157366; -.
DR HOGENOM; CLU_001390_4_1_1; -.
DR InParanoid; G3W5P8; -.
DR TreeFam; TF314204; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 791..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 858..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 888..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 927..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..336
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 798..1039
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1133..1188
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 1231..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1581..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1604 AA; 183222 MW; 847F67F658775164 CRC64;
MCHRCCCGRL IGQHVGLTPS ISVIQNEKNE SRLSRNDIQS EKWSISKHTQ LSPTDAFGTI
EFQGGGHSNK AMYVRVSFDT KPDLLLHLMT KEWQLELPKL LISVHGGLQN FELQPKLKQV
FGKGLIKAAM TTGAWIFTGG VNTGVIRHVG DALKDHASKS RGKICTIGIT PWGIVENQED
LIGKDVVRPY QTMSNPMSKL TVLNSMHSHF ILADNGTTGK YGAEVKLRRQ LEKHISLQKI
NTRIGQGVPV VALIVEGGPN VISIVLEYLR DTPPVPVVVC DGSGRASDIL AFGHKYSEEG
GLINESLRDQ LLVTIQKTFT YTRTQAQHLF IILMECMKKK ELITVFRMGS EGHQDIDLAI
LTALLKGANA SAPDQLSLAL AWNRVDIARS QIFIYGQQWP VGSLEQAMLD ALVLDRVDFV
KLLIENGVSM HRFLTISRLE ELYNTRHGPS NTLYHLVRDV KKGNLPPDYR ISLIDIGLVI
EYLMGGAYRC NYTRKRFRTL YHNLFGPKRP KALKLLGMED DVPLRRGRKT TKKREEEIDI
DLDDPEINHF PFPFHELMVW AVLMKRQKMA LFFWQHGEEA MAKALVACKL CKAMAHEASE
NDMVDDISQE LNHNSRDFGQ LAVELLDQSY KQDEQLAMKL LTYELKNWSN ATCLQLAVAA
KHRDFIAHTC SQMLLTDMWM GRLRMRKNSG LKVILGILLP PSILSLEFKN KDDMPYMSQA
HEIHLQEKEP EEPEKTVKEK DEEDMELTAM LGRSNGESSR KKDEEEVQSR HRLIPLGRKI
YEFYNAPIVK FWFYTLAYIG YLMLFNYIVL VKMERWPSTQ EWIVISYIFT LGIEKMREIL
MSEPGKLFQK VKVWLQEYWN VTDLIAILLF SVGMILRLQD QPFRSDGRVI YCVNIIYWYI
RLLDIFGVNK YLGPYVMMIG KMMIDMMYFV IIMLVVLMSF GVARQAILFP NEEPSWKLAK
NIFYMPYWMI YGEVFADQID PPCGQNETRE DGKIVQLPPC KTGAWIVPAI MACYLLVANI
LLVNLLIAVF NNTFFEVKSI SNQVWKFQRY QLIMTFHERP VLPPPLIIFS HMTMIFQHLC
CRWRKHESDP DERDYGLKLF ITDDELKKVH DFEEQCIEEY FREKDDRFNS SNDERIRVTS
ERVENMSMRL EEVNEREHCM KASLQTVDIR LAQLEDMIGR MATALERLTG LERAESNKIR
SRTSSDCTDA AYIVRQSSFN SQEGNTYKVQ ESLDPTGEGS MSPTSPTLMP RMRSHSFYSM
NIKDKSDIEK LESIFKERSL SLHRATSSHS VSKETKAVPI PISTLAIIPD SRRPSSCIDI
YVSAMDELQG DIDPLDNSMN ILGLEEPIFP APTTSTAPSS SAYATLAPTD RLPSRSMDFE
DITSMDTRSF SSDYTHLLPE CPNPWDVDPP LYHAIERSKS SRYLATTPFL LEEAPIVKSH
SFMFSPPRNY YTNFGVSVKT AEYTSITDCI DTRCVNAPQA IADRMIFPGA LGDKVEDLAS
NHPEREAELS HPSSDNEENE AKDRKTLTLP TQGGSISDRI LSNNIALPKI ERANSCYAEE
PSTLYPHTRK SFSISDKLDR QRNTAGNTAS LRHPFQRKHP FCSV
//
