ID G3W9F1_SARHA Unreviewed; 1005 AA.
AC G3W9F1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=TOG array regulator of axonemal microtubules 2 {ECO:0000313|Ensembl:ENSSHAP00000012056.2};
GN Name=TOGARAM2 {ECO:0000313|Ensembl:ENSSHAP00000012056.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012056.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000012056.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012056.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012395294.1; XM_012539840.1.
DR AlphaFoldDB; G3W9F1; -.
DR STRING; 9305.ENSSHAP00000012056; -.
DR Ensembl; ENSSHAT00000012154.2; ENSSHAP00000012056.2; ENSSHAG00000010336.2.
DR GeneID; 100931101; -.
DR KEGG; shr:100931101; -.
DR CTD; 165186; -.
DR eggNOG; KOG2933; Eukaryota.
DR GeneTree; ENSGT00940000156217; -.
DR HOGENOM; CLU_306027_0_0_1; -.
DR InParanoid; G3W9F1; -.
DR TreeFam; TF315518; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF42; TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 2; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 488..731
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 770..1005
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 25..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 111062 MW; F4FE39A628A6CD86 CRC64;
MATRDDVTSA KFRVPVAVYC GSVPRSSTSS GFRSFHGPNR NVNSSLQDYG DRWTGEASPQ
SLLKVQMEKQ SSVWGRNGDL TSLKTSLASK AWQSRNGHVK NAEANSSVAP PLLPATVKEM
EANSAALETT QIKDKLKKRR LSEGWSASPR ASLDPGGVTK GTSLKSAMPR STSQRFLTVS
RPMPPIQSIP TTPEAKGSLE NGSAPQRISK SRLRATPAAQ EVQISLQYLH CKDEKIRRSL
GGALIPSIPK PGQPAETKSV TLPAVVSNSI PLPPGQDVLT FQEAPRIRLA QENNSQEKTP
KSMEAKSVVP PAQVGPSGGT KPAVHSSQTA SPLKTPSLSR ANKDERTRTQ QLLKEMDRPQ
SNSRIQVTIS KSAQEKMRLK QMKEMELFQR GREREEGQRE RDFLSQNLNS RSMMKEGLIS
LHGSPSVSAK LGSPCRTSLG IILKKRANRS SLPSIPVSSQ GPRFTRHASA NSLPAVFTVG
TPEWEEEEII NNNSKELRPL SNPELVLMNA LQWLESNDWQ MKEKGLVSIR RLATCHSEVL
AERLHDVSLA VLGEVPNLRS KVCRLAISTL GDLFRTMKKN MDPEVEEIAR CLLQKMGDTN
EFIHRAADRS LGAMVENVTP SKSLAALTTG GVHHRNPLIR KCAAEHLCNV VEQIGADKLL
SGTRESTDML IRTMVKLAQD SNKDTRFCGR KMMNTLMSNA RFDAFLKQSF PSHDLCDVMA
TIKQKGVEEN IEPPPIKGRK IKNSIASEEI RITEQGCSAE IEPVVVHRSN IRNPEMIEQL
KELSSLLQSK EYRTRMEGIT LLLAHCKNNH NFITANLTQI FDIFIPRLQD PNKKVNQCAL
EVFTEMIPHL KDNLHPVLVS VVTVVSDNLN SKSSAIYGAA VMALDAMIEN IDNFSLLQAF
AGRLCFLSGR AMCDITQRLS VLVTSVYSRK PQSVERHVLP VLWYFLNNMI GNGVLPGHSG
NVRSVVCQLT KSLYEQMGTR LRDCAAGQPK QVSKMLQDIL DSNFQ
//
