ID G3WEY5_SARHA Unreviewed; 508 AA.
AC G3WEY5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=aldehyde dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00024226};
DE EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
GN Name=LOC100919222 {ECO:0000313|Ensembl:ENSSHAP00000013990.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000013990.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000013990.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000013990.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR RefSeq; XP_012398358.1; XM_012542904.1.
DR AlphaFoldDB; G3WEY5; -.
DR Ensembl; ENSSHAT00000014107.2; ENSSHAP00000013990.2; ENSSHAG00000011965.2.
DR GeneID; 100919222; -.
DR KEGG; shr:100919222; -.
DR GeneTree; ENSGT00940000154609; -.
DR HOGENOM; CLU_005391_0_1_1; -.
DR InParanoid; G3WEY5; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07141; ALDH_F1AB_F2_RALDH1; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF140; ALDEHYDE DEHYDROGENASE 1A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 36..499
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 276
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 508 AA; 55756 MW; 9078802533050C1A CRC64;
MSSKEKTPTN LGEGNIPAPL FNCKIQYTKI FINNEWHDSV SGKKFPVINP ATEEKICDVE
EGDKEDVDKA VKAARKAFQI GSPWRTMDAS ERGRLLNKLA DLMERDYLLL ATIESMNGGK
VFSHAYQLDL GFSVRTLRYC ASWADKIQGR TIPIDGKFFS YTRHEPIGVC GQIIPWNFPL
VSLVWKIGPA LCCGNTVVVK PAEQTPLTAL HVASLIKEAG FPPGVVNIVP GYGPTAGAAI
SSHMDVDKVS FTGSTEVGLL IKQAAGKSNL KRVTLELGGK SPCIVFADAD LDNAVEFAHH
GVFFHQGQCC IAASRLFVEE SIYDEFVKRS VERAKKYTLG DPLKPGVQQG PQIDKEQYNK
ILDLIESGLK QGAKLECGGG PWGDKGYFIQ PTVFSNVTDE MRIAKEEIFG PVQQIMKFKT
IDEVIKRANN THYGLAAGIF TKDLDKALTI SSALQAGTVW VNCYSVTSPQ APFGGFKMSG
NGREMGEYVL HEYLEVKTVT IKISEKNS
//
