ID G3WM89_SARHA Unreviewed; 499 AA.
AC G3WM89;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
GN Name=LOC100915011 {ECO:0000313|Ensembl:ENSSHAP00000016544.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016544.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000016544.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000016544.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_003772268.1; XM_003772220.1.
DR AlphaFoldDB; G3WM89; -.
DR Ensembl; ENSSHAT00000016682.2; ENSSHAP00000016544.1; ENSSHAG00000014072.2.
DR GeneID; 100915011; -.
DR KEGG; shr:100915011; -.
DR GeneTree; ENSGT00940000154026; -.
DR HOGENOM; CLU_012560_5_0_1; -.
DR InParanoid; G3WM89; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF52; KERATIN, TYPE II CUTICULAR HB6; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 107..418
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 160..243
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 316..396
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 499 AA; 54365 MW; EE21E0ED0BE29E15 CRC64;
MTCGSYCGGS VRAFSCASAC GPRPGRCCVT AAPYRGVSCY RGLSGFGSRS FCGGYRAGSC
GRSFGYRSGG VCGPSPPCIT TVSVNESLLT PLNLEIDPNA QCVKHEEKEQ IKCLNSKFAA
FIDKVRFLEQ QNKLLETKWQ FYQNRKCCES NLEPLFQGYI ETLKRELECV EADSGRLASE
LNHVQEVLEG YKKKYEEEVS LRATAENEFV ALKKDVDCAY LRKSDLEANT EALIEEINFL
RALYEEEIRV LQSHISDTSV VVKMDNSRDL NMDCVIAEIK SQYDDIASRS RAEAESWYRS
KCEEMKATVI RHGETLRRTK EEINELNRMI QRLTAEVENA KCQNSKLEAA VTQSEQQGEA
ALNDARCKLA GLEEALQKAK QDMACLLKEY QEVMNSKLGL DIEIATYKRL LEGEEQRLCE
GVGAVNVCVS SSRGGVVCGD LCTSTSGARV VSSGSSGPSG GSVVVSAPNA CAPCGGGSGV
GTGCSIRSCG TSCCGVKRC
//
