ID   G3WNJ3_SARHA            Unreviewed;       507 AA.
AC   G3WNJ3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Keratin 85 {ECO:0000313|Ensembl:ENSSHAP00000016998.2};
GN   Name=KRT85 {ECO:0000313|Ensembl:ENSSHAP00000016998.2};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016998.2, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000016998.2, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000016998.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_003772251.1; XM_003772203.1.
DR   AlphaFoldDB; G3WNJ3; -.
DR   STRING; 9305.ENSSHAP00000016998; -.
DR   Ensembl; ENSSHAT00000017140.2; ENSSHAP00000016998.2; ENSSHAG00000014450.2.
DR   GeneID; 100932290; -.
DR   KEGG; shr:100932290; -.
DR   eggNOG; ENOG502SK5S; Eukaryota.
DR   GeneTree; ENSGT00940000162337; -.
DR   HOGENOM; CLU_012560_5_0_1; -.
DR   InParanoid; G3WNJ3; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF43; KERATIN, TYPE II CUTICULAR HB5; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT   DOMAIN          123..434
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          176..266
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          332..412
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   507 AA;  55874 MW;  6D4AC7A90AA963A5 CRC64;
     MSCRSYRISS GCGITRNFSS CSAVAPKTGN RCCISAAPYR GVSCYRGITG FGSRSLCNVG
     SCGPRISMGG YRSIGCGRSF GYRSGGVCGP SPPCITTVSV NESLLTPLNL EIDPNAQCVK
     HEEKEQIKCL NSKFAAFIDK VRFLEQQNKL LETKWNFYQN QRCCQSNMEP LFNGYIETLK
     RELECVEADS GRLSSELNHM QEVLEGYKKK YEEEVALRAT AENEFVVLKK DVDCAYLRKS
     DLEANAEALT EEINFLKALY EEEIRVLQSQ ISDTSVIVKM DNSRDLNMDC IVAEIKAQYD
     DIASRSRAEA ESWYRTKCEE MKATVIRHGE SLRRTKEEMN ELNRIIQRLT AEIENAKCQR
     CKLEAAVAEA EQQGEAAIND AKCKLAELEG ALQKAKQDMA CLLKEYQEVM NSKLGLDIEI
     ATYKRLLEGE EHRLCEGVGS VNVCVSSSRG GVTCGGLTCS TTSGLQISSG PSASGGSYTV
     MAPDSCAPCQ PRSLGFSCGS SRSVRFA
//