ID G3WQL3_SARHA Unreviewed; 1223 AA.
AC G3WQL3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Cache domain containing 1 {ECO:0000313|Ensembl:ENSSHAP00000017718.2};
GN Name=CACHD1 {ECO:0000313|Ensembl:ENSSHAP00000017718.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000017718.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000017718.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000017718.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
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DR AlphaFoldDB; G3WQL3; -.
DR STRING; 9305.ENSSHAP00000017718; -.
DR Ensembl; ENSSHAT00000017864.2; ENSSHAP00000017718.2; ENSSHAG00000015047.2.
DR eggNOG; KOG2353; Eukaryota.
DR GeneTree; ENSGT00940000157568; -.
DR HOGENOM; CLU_004521_0_0_1; -.
DR InParanoid; G3WQL3; -.
DR TreeFam; TF315824; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF66; VWFA AND CACHE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00092; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1045..1066
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..378
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1128..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1223 AA; 136934 MW; 5454585D5B27E7BD CRC64;
MRRLAAEELG VVTMQRIFNS FVYTEKISNG ETEVQQLAKK IREKFNRYLD VVNRNKQVVE
ASYTAHLTSP LTAIQDCCTI PPSMMEFDGN FNTNVSRTIS CDRLSTTVNS RAFNPGRDLN
SVLADNLKSN PGIKWQYFSS EEGIFTVFPA HKFRCKGGYE HRSRPVYVST VRPQSKHIVV
IMDHGASVTE TQLQIAKDAA QVILNSIDEH DKISVLTVAD TVRTCSLDQC YKTFLSPATS
ETKRKMSTFV SSIKSSESPT QHAVGFQKAF QLIRSTNNGT RLHTNTDMVI IYLSAGITSK
ESSEEDKKAT LCVINEENSF LNNSVMILTY ALMNDGVTGL KELAFLRDLA EQNSMKYGVP
DRTTLPVIKG SMMVLNQLSN LETTVGRFYT NLPNRMIDEA VFSLPFSDEM GDGLIMTVSK
PCYFGNLLLG IVGVDVNLAY ILEDVTYYQD SLASYTFLID DKGYTLMHPS LTRPYLLSEP
PLHTDIIHYE NIPKFELVRQ NILSLPLGSQ IITVPVNSSL SWHINKLRET GKEAYNVSYA
WKMVQDTSFI LCIVVIQPEV PVRQLKNLNT VPSSKLLYHR LDLLGQPSAC LHFKQLSTLE
SPTVMLSAGS FSSPYEHLSQ PETKRMVEHY TAYLSDNTRL IANPGLKFSV RNEVMATSHV
TDEWMTQMEM SSLNTYIVRR YIATPNGVLR IYPGSLMDKA FDPTRRQWYL HAVANPGLIS
LTGPYLDVGG AGYVVTISHT VHSSSSQMSS GHTVAVMGID FTLRYFYKVL MDLLPVCNQD
GGNKIRCFIM EDRGYLVAHP TLIDPKGHAP VEQQHITHKE PLVANDILNH PNFVKKNLCN
SFSDRTVQRF YKFNTSLVGD LTNLVHGSHC SKYRLTRIPG TNAFVGIVNE TCDSLAFCAC
SMVDRLCLNC HRMEQNECEC PCECPLEVNE CTGNLTNAEN RNPSCEVHQE PVTYTAIDPG
LQDALPQCVN SRCNQRMESG DCFGVLDCEW CMVDSDGKTH LDKSYCAPQK ECFGGIVGAK
SPYVDDMGVI GDEVITLNMV KSAPVGPVAG GIMGCIMVLV LAVYAYRHQI HRRSHQHMSP
LAAQEMSVRM SNLENDRDER DDDSHEDRGI ISNTRFIAAV IERHAHSPER RRRYWGRSGT
ESDHGYSTMS PQEDSENPPG NNDPLSAGVD VGNHDEDLDL DTPPQTAALL SHKFHHYRLH
HPTLHHNHHL QAAVTVHTVD AEC
//
