ID G3WSH3_SARHA Unreviewed; 393 AA.
AC G3WSH3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Decaprenyl diphosphate synthase subunit 2 {ECO:0000313|Ensembl:ENSSHAP00000018378.2};
GN Name=PDSS2 {ECO:0000313|Ensembl:ENSSHAP00000018378.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000018378.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000018378.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000018378.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3WSH3; -.
DR STRING; 9305.ENSSHAP00000018378; -.
DR Ensembl; ENSSHAT00000018530.2; ENSSHAP00000018378.2; ENSSHAG00000015599.2.
DR eggNOG; KOG0776; Eukaryota.
DR GeneTree; ENSGT00940000153498; -.
DR HOGENOM; CLU_014015_3_1_1; -.
DR InParanoid; G3WSH3; -.
DR TreeFam; TF354277; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990234; C:transferase complex; IEA:Ensembl.
DR GO; GO:0097269; F:all-trans-decaprenyl-diphosphate synthase activity; IEA:Ensembl.
DR GO; GO:0052923; F:all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0000010; F:trans-hexaprenyltranstransferase activity; IEA:Ensembl.
DR GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0050878; P:regulation of body fluid levels; IEA:Ensembl.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:Ensembl.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR PANTHER; PTHR12001:SF55; ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2; 1.
DR PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
PE 3: Inferred from homology;
KW Isoprene biosynthesis {ECO:0000256|ARBA:ARBA00023229};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transferase {ECO:0000256|RuleBase:RU004466}.
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 43546 MW; 03ECEF7314AAB154 CRC64;
MSLRELLRRP RRPGTPSALW RPLLRPPPAP RRSLFSGSPT HWNQVVSEAE KIVGYPTSFM
SLRCLLSDEL SNIAMQVRKL VGTRHPLLYT ARRLVQDSRN NLQLRGLVVL LISKAAGPSN
TAVLPLKHDM VSGIYPSQRS LAEITELIHT AFLVHRGIVN LSELNSSDGP LKDMQFGNKI
AILSGDFLLA NACTGLAQLQ NTKVVELVSS ALIDLVQGIY CEKSTSTEEN CITDDIGIST
WKEQIFLSHS ALLAKSCQAA MELAKHDTEV QDMAFQYGKH MSMSHKINSD LQPFIRGKCA
GSITFNLNSA PVVLHQEFLG REMWIKQIRE AQEKGTLDYS KLQEAILAGK GVTSAIDLCR
YHGNKALEAL ECFPPSEARS ALENIVYAVT RFP
//
