ID G3X0L2_SARHA Unreviewed; 926 AA.
AC G3X0L2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein {ECO:0000259|Pfam:PF20408};
GN Name=KANSL3 {ECO:0000313|Ensembl:ENSSHAP00000021217.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000021217.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000021217.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000021217.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3X0L2; -.
DR STRING; 9305.ENSSHAP00000021217; -.
DR ESTHER; sarha-g3x0l1; NLS3-Tex30.
DR Ensembl; ENSSHAT00000021389.2; ENSSHAP00000021217.2; ENSSHAG00000017986.2.
DR eggNOG; KOG3253; Eukaryota.
DR GeneTree; ENSGT00390000007636; -.
DR HOGENOM; CLU_009783_0_0_1; -.
DR InParanoid; G3X0L2; -.
DR OrthoDB; 5405548at2759; -.
DR TreeFam; TF323466; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0044545; C:NSL complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR046879; KANL3/Tex30_Abhydrolase.
DR InterPro; IPR026555; NSL3/Tex30.
DR PANTHER; PTHR13136:SF16; KAT8 REGULATORY NSL COMPLEX SUBUNIT 3; 1.
DR PANTHER; PTHR13136; TESTIS DEVELOPMENT PROTEIN PRTD; 1.
DR Pfam; PF20408; Abhydrolase_11; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 333..461
FT /note="KANL3/Tex30 alpha/beta hydrolase-like"
FT /evidence="ECO:0000259|Pfam:PF20408"
FT REGION 475..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 98781 MW; 6DB4198CE2420986 CRC64;
MSHRGGERDF QTSARRMGTS LLFQLSVHER ELDLVFLDHS YAKPWSAHPD ASSARPTRML
FVTPRRHQDS TIEADIPIDV ETVTSTPVPL YDNQKARSVM NECERHVIFA RTDADAPPPP
EDWEEHVNRT GWTIAQNKLF NKILKALQSD RLARLANEGA CNEPVLRRIA VDKCARRVRQ
ALASVSWDIK LVQWLHTTLV ETLSLPMLAA YLDALQTLKG KIPTLIDRML MSSTTKTGAA
GAEALSLLLK RPWDPAVGVL SHNKPSKLPG SPLILIASSG PSSSMFPTSR RHRFWQSQLS
CLGKVIPIAT HLLNNGSGVG VLQCLEHMIG AVRGKVLEIH NHFPHKPIIL IGWNTGALVA
CHVSVMEYVT AVVCLGFPLL TVDGPRGDVD DPLLDMKTPV LFVIGQNSLQ CHTEAMEDFR
EKIRADNSMV VVGGADDNLR ISKAKKKSEG LTQSMVDRCV QDEIADFLTG VLTRAEGHSG
SEPRDQDAEK KKKPRDSARR DLAFELPERG SRPTSPSAKL PASPSGSEDL SSVSSSPTSS
PKTKVATMTS APKSSQIGTA QLLKRHVQRT EAVLTHKQAQ AQFAAFLKQN MLVRKTLPPG
TSSCLFVPIS SDQAEEVDKE DLRGQLKRQH PPSPPPGSKA SKRAKIKVTI VSHGDGTSGP
SLPSQGGTTE VSGGKPITVT RGQAAVGAKE LTGLLTTTKS SAASEAVSVS PASSSIIPNS
TAPSAFHTLQ SRLVASGGHC VAASPGSTLP GSTSASSLLQ GLSFSLQDIS SKTPTLPANA
SPGPATQTTS VKLPTPMQSL GAITTGTGTI VRTIPVATTL SSLGATPGGK PTAIHQLLTN
GGLAKLASSL PGLAQISNQA AGLKAPTTIT VTLRGQPSRV TTLSPMGTGA ASLEESTSQA
LPSTPQNDEF LEIMNSRRAT WWEMMK
//
