ID G3X338_SARHA Unreviewed; 412 AA.
AC G3X338;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Potassium channel tetramerization domain containing 2 {ECO:0000313|Ensembl:ENSSHAP00000022093.2};
GN Name=KCTD2 {ECO:0000313|Ensembl:ENSSHAP00000022093.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000022093.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000022093.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000022093.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3X338; -.
DR STRING; 9305.ENSSHAP00000022093; -.
DR Ensembl; ENSSHAT00000022270.2; ENSSHAP00000022093.2; ENSSHAG00000018698.2.
DR eggNOG; KOG2715; Eukaryota.
DR GeneTree; ENSGT00940000158336; -.
DR HOGENOM; CLU_070830_0_1_1; -.
DR InParanoid; G3X338; -.
DR TreeFam; TF313754; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18389; BTB_POZ_KCTD2; 1.
DR Gene3D; 3.30.70.2000; -; 1.
DR Gene3D; 6.10.140.750; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14958:SF22; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD2; 1.
DR PANTHER; PTHR14958; POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 221..324
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 44566 MW; 975F83F1CD222BB4 CRC64;
MRSAPSNHTA ETPVRIMGGT GGGLLGKLQM PKRARARSKG EKGSTTTHLQ RPRRRTARDR
KQPEERHRKS PSNQSLYGRG SSSVSRDQWD SKRVPETPPP GNGGVPGSGW GAAPSFLCRW
AGPALPASEW EWAGPGMRGQ EGSKMAEVDS TVGGGGLGDC RVPASASPRS SSSSAAAASA
ASSRGHGRLA AAATASTLSS APQPPSQPGP GPPERAGGAG RWVRLNVGGT YFVTTRQTLG
REPKSFLCRL CCQEDPELDS DKDETGAYLI DRDPTYFGPI LNYLRHGKLI INKELAEEGV
LEEAEFYNIA SLVRLVKERI RDNENITSQG PVKHVYRVLQ CQEEELTQMV STMSDGWKFE
QLINIGSSYS YGNEDQTEFL CVVSRELNNS TNGIVIEPSE KAKILQERGS RM
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