ID G3YH87_ASPNA Unreviewed; 1074 AA.
AC G3YH87;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=NRPS-like enzyme {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPNIDRAFT_38316 {ECO:0000313|EMBL:EHA18084.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA18084.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA18084.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA18084.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACJE01000021; EHA18084.1; -; Genomic_DNA.
DR AlphaFoldDB; G3YH87; -.
DR STRING; 380704.G3YH87; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1188789; -.
DR HOGENOM; CLU_002220_0_0_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR PANTHER; PTHR43439:SF2; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR43439; PHENYLACETATE-COENZYME A LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 24..353
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 574..637
FT /note="Carrier"
FT /evidence="ECO:0000259|Pfam:PF00550"
FT DOMAIN 680..914
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT COILED 640..669
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1074 AA; 119212 MW; 0FBFDB4A0B278563 CRC64;
MTVPDVSQFN PRTQLLPHIV DHYAKVKPDA IYAEYPVSLM SYDDGYRPIT FKAFANAING
IAWWLTEKLG PGDGETLAYV GPNDLRYPAL VLGAVKAGYR MFLTSPRNSV AAHSSLFNRL
SCTKLVTPVP HPPPVKAILE GQTLDVLEVP SVDELISKEY AHFEFSKTYP EAAGEILAVI
HTSGSTGIPK PIFWSHDSAC KHMHTTVLDP PKGHESQDSW LFGKRIFLVP PPFHAAGLAY
SLFLTIPVGT TVIFPASGGL PTAASLVEAR KKTQIDILLG VPSIIQEFSQ SPELLDYCSK
HLDRLVYCGG DLPQPIGDAV ASKIKLMNLY GASEVGMIST IHSKTNRDPR TDWRYLHINP
RMGAELRHVA DQYYELVIVR SPKSEKHQLS FTIFPDQQEY HTKDLFVRHP DPSKPDLWRW
AARADDVIVF LNGEKTNPVS MEQHIAASNP EVTAVLVAGA RRFQASLLVE IGGKDLTAHE
RAAMIEKVWP SVEEANAVCP AHARVAKTHI LFTKPDKPML RAGKGTIQRA ASLELYTSEL
DALYADADKL SQATSNGEPA RPGQVDDPKV LSDYIRRTIN YVTGWDLTDN QNFFELGLDS
LQAITATRAF KNGLDLPTLT PNLIYLHPSV DELTQAVLHL QQHEEASAEE KKEAQLQQRE
ELLQELSSQF QAPKSHVVIL TGSTGNLGSY LLDTLLQSPS VTYVHCLNRN PDAEASHRVK
RNGMKTDLSR VSFWTADLSQ PDLGLGPDVF KTLRNIATLI IHNAWAVNFN LSLSSFKPNL
TGVVNLINFA AQSHQSPHLF FLSSISSTMG HHTKTGLTPE EVITTTNPGP NGYADSKYLA
EQLLAQAARQ GRVHASFARV GQIAGPVRSK GVWNQTEWFP SLVRSSFHLG ILPDTLGPAL
NRIDWVPVDL LAEVLVDLAV AGQGVGTRGV QVYHPLNLHP VDWEVIRPMV AEALFKVSRK
TIETVPFNEW VQRVRQDLEM AGSTGEKMSD EELQKRLAKN PAAKLLEFFE GIMSQAERAN
VLDTRLTGQI SEKLRAVDAV KPEWIYMWVE GWIRRELVVD WSCFARESGV WKRT
//
