ID G4LVA3_SCHMA Unreviewed; 395 AA.
AC G4LVA3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Adenylate kinase 8 {ECO:0000256|ARBA:ARBA00029501};
DE EC=2.7.4.3 {ECO:0000256|ARBA:ARBA00012955};
DE EC=2.7.4.6 {ECO:0000256|ARBA:ARBA00012966};
DE AltName: Full=ATP-AMP transphosphorylase 8 {ECO:0000256|ARBA:ARBA00042874};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_197230.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_197230.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_197230.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the
CC reversible transfer of the terminal phosphate group between nucleoside
CC triphosphates and monophosphates. Has highest activity toward AMP, and
CC weaker activity toward dAMP, CMP and dCMP. Also displays broad
CC nucleoside diphosphate kinase activity.
CC {ECO:0000256|ARBA:ARBA00037483}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000582};
CC -!- SIMILARITY: Belongs to the adenylate kinase family.
CC {ECO:0000256|RuleBase:RU003330}.
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DR RefSeq; XP_018644648.1; XM_018791647.1.
DR AlphaFoldDB; G4LVA3; -.
DR STRING; 6183.G4LVA3; -.
DR EnsemblMetazoa; Smp_197230.1; Smp_197230.1; Smp_197230.
DR GeneID; 29830176; -.
DR KEGG; smm:Smp_197230; -.
DR WBParaSite; Smp_197230.1; Smp_197230.1; Smp_197230.
DR CTD; 29830176; -.
DR eggNOG; KOG3078; Eukaryota.
DR HOGENOM; CLU_044905_0_0_1; -.
DR InParanoid; G4LVA3; -.
DR OrthoDB; 314591at2759; -.
DR PhylomeDB; G4LVA3; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050145; F:nucleoside monophosphate kinase activity; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd01428; ADK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00235; Adenylate_kinase_Adk; 1.
DR InterPro; IPR000850; Adenylat/UMP-CMP_kin.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23359:SF81; ADENYLATE KINASE 8; 1.
DR PANTHER; PTHR23359; NUCLEOTIDE KINASE; 1.
DR Pfam; PF00406; ADK; 1.
DR PRINTS; PR00094; ADENYLTKNASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003330};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003330}.
SQ SEQUENCE 395 AA; 44949 MW; 3D8A9E1582B9743F CRC64;
MLQVKLQCTI IHGDDVYSLC QEGKNAPVQK LIAALKKQLD ESDCESRGYI IVDFPRCEKE
AKALINEGIF PDYAIFLDAP LLTLIERASG ERMDPDNGDL YNLIHNPPSD LSVEKRLVKI
TENDEELIKN HYSEYNRQMV LLKRIYSSVA HEFNADQPIN DLYHSVLAKV NQCRRSVALQ
TPKIILLGYP GAGKHTQANL LAKKYGLIPV DCGQLILREI ANRSSVGNIM KTYVQKNIPV
PDAIVSEVVK NRLNEIDCIT YGWILVGYPR TRQQAELLSS HKVYPTRVIL MDVHQSCASE
RLSGRRMDPI TGIRFHTAFE SVEDVCISQR ALQRPNDEEN AIGPKLSRFT ANRDDIIEYY
DPYVVKVHAD RDIHTVYEEI ETAIVNPLPR FNFVK
//
