ID G4NMJ2_CHLT4 Unreviewed; 368 AA.
AC G4NMJ2; H1ZNK4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=16S rRNA m(5)C 967 methyltransferase {ECO:0000313|EMBL:AEP35420.1};
GN OrderedLocusNames=CTO_0603 {ECO:0000313|EMBL:AEP35420.1};
OS Chlamydia trachomatis serovar A (strain A2497).
OC Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=580047 {ECO:0000313|EMBL:AEP35420.1, ECO:0000313|Proteomes:UP000009287};
RN [1] {ECO:0000313|EMBL:AEP35420.1, ECO:0000313|Proteomes:UP000009287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A2497 {ECO:0000313|EMBL:AEP35420.1,
RC ECO:0000313|Proteomes:UP000009287};
RX PubMed=21987657; DOI=10.1084/jem.20111266;
RA Kari L., Whitmire W.M., Olivares-Zavaleta N., Goheen M.M., Taylor L.D.,
RA Carlson J.H., Sturdevant G.L., Lu C., Bakios L.E., Randall L.B.,
RA Parnell M.J., Zhong G., Caldwell H.D.;
RT "A live-attenuated chlamydial vaccine protects against trachoma in nonhuman
RT primates.";
RL J. Exp. Med. 208:2217-2223(2011).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; CP002401; AEP35420.1; -; Genomic_DNA.
DR AlphaFoldDB; G4NMJ2; -.
DR KEGG; cra:CTO_0603; -.
DR KEGG; cty:CTR_5561; -.
DR PATRIC; fig|580047.4.peg.611; -.
DR Proteomes; UP000009287; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807:SF30; 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 105..368
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 320
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 228
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 267
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 368 AA; 42064 MW; 3D15CC585B7BD37F CRC64;
MIPFRFHHLY ILLDSLFSSP IGESNRVAAY FKEHPSLGSK DRQWINTRIF TILRHRRLLE
ALVLAEGKEI SAQTLVEKVE EGVTENIEQF QHLPWPVRYS ISDDLAECLT TDYGEEEAIR
LAKIFLEEAP CSIRVNTRRI SVDKLQKVLP FPCQRGAAPS SLRFEKRYPL QHTRAFRRGL
FEIQDESSQI ITNAILIKDS DTVLDFCAGA GGKSLIFAQR ARHVTLHDSR PQALEEARHR
LSRSGIKNFT IPSQPLKKHS FSLVVVDAPC TGSGVFRRHP EKKLLFSKQL LHNNSIAQER
ILKEALAYVA PCGRLVYITC SLMKEENEKH TSWMASQGWK CVKEVKIPLV SRQGDAFFSS
HFIRSRSL
//
