ID G4NNX1_CHLT4 Unreviewed; 628 AA.
AC G4NNX1; H1ZQD5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Signal peptidase I {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
DE EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
GN OrderedLocusNames=CTO_0022 {ECO:0000313|EMBL:AEP34826.1};
OS Chlamydia trachomatis serovar A (strain A2497).
OC Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=580047 {ECO:0000313|EMBL:AEP34826.1, ECO:0000313|Proteomes:UP000009287};
RN [1] {ECO:0000313|EMBL:AEP34826.1, ECO:0000313|Proteomes:UP000009287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A2497 {ECO:0000313|EMBL:AEP34826.1,
RC ECO:0000313|Proteomes:UP000009287};
RX PubMed=21987657; DOI=10.1084/jem.20111266;
RA Kari L., Whitmire W.M., Olivares-Zavaleta N., Goheen M.M., Taylor L.D.,
RA Carlson J.H., Sturdevant G.L., Lu C., Bakios L.E., Randall L.B.,
RA Parnell M.J., Zhong G., Caldwell H.D.;
RT "A live-attenuated chlamydial vaccine protects against trachoma in nonhuman
RT primates.";
RL J. Exp. Med. 208:2217-2223(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000677,
CC ECO:0000256|RuleBase:RU362042};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362042}; Single-
CC pass type II membrane protein {ECO:0000256|RuleBase:RU362042}.
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370, ECO:0000256|RuleBase:RU362042}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362042}.
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DR EMBL; CP002401; AEP34826.1; -; Genomic_DNA.
DR AlphaFoldDB; G4NNX1; -.
DR KEGG; cra:CTO_0022; -.
DR KEGG; cty:CTR_0201; -.
DR PATRIC; fig|580047.4.peg.26; -.
DR Proteomes; UP000009287; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 2.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 2.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019533; Peptidase_S26.
DR NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF10502; Peptidase_S26; 2.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362042};
KW Membrane {ECO:0000256|RuleBase:RU362042};
KW Protease {ECO:0000256|RuleBase:RU362042};
KW Transmembrane {ECO:0000256|RuleBase:RU362042};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362042}.
FT TRANSMEM 81..103
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 601..620
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT DOMAIN 84..201
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT DOMAIN 530..581
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 113
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 183
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 628 AA; 71456 MW; 22CA1F0087E78C6F CRC64;
MTSSYMSRLY SLNKSRRILH SSFRLLKSTK MLSHPETQKE LQEVLKQLEE AILDQNREDA
SLFAKQAQAI QKRFPKSKLR ATFDLIYALT FAAILAFLIR QFWFELYEVP TGSMRPTILE
QDRILVSKTT FGLRLPFSNK SIGYTPEAIT RGELVVFTVG DLPIPSADTK YFGIIPGKKR
YIKRCMGKPG DTVYFYGGKI YGIDCDGEPI FPQNTENLYH VPYISFDGTP EILTHSEEQT
DVIFNQFHTP CGKISLPQQA SYGQFFYKNA WHNDTPYALK DPHNEPVSYA DLFGIKNFAI
VRILTKKQAA LTHVLPSPLS DTYLEIAHTP NVSYPHPHLR PFETQLIPTI EPMKTLLPLR
KEHIHLIRNN LTTSRFTVVD GYAYKYQPAP MNTSGMARMF ALPMPNIPDG CYEFSKGDVF
KINMGGFRTK LKQPHPLTQL SNSQVIDLFN CGISFHTIYI PKNPQYAPFP NRYAFFHQGN
LFVMDSPVFI DSDPALQKFI VSEEEKELQS SEDKPYIAFI DRGPPPESTE EFVSFITNFG
LKIPEGHVLV LGDNCPMSAD SRDFGFVPVE NLLGSPVGIF WPINRLGLLS SNITPLSLPG
YLVNGLALGA FLYCIGLWYY RKNHRLFP
//
