ID G4SW44_META2 Unreviewed; 406 AA.
AC G4SW44;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:CCE21965.1};
GN OrderedLocusNames=MEALZ_0265 {ECO:0000313|EMBL:CCE21965.1};
OS Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylotuvimicrobium.
OX NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE21965.1, ECO:0000313|Proteomes:UP000008315};
RN [1] {ECO:0000313|Proteomes:UP000008315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC {ECO:0000313|Proteomes:UP000008315};
RX PubMed=22207753; DOI=10.1128/JB.06392-11;
RA Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA Trotsenko Y.A., Kalyuzhnaya M.G.;
RT "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT Methylomicrobium alcaliphilum 20Z.";
RL J. Bacteriol. 194:551-552(2012).
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO082060; CCE21965.1; -; Genomic_DNA.
DR AlphaFoldDB; G4SW44; -.
DR STRING; 1091494.MEALZ_0265; -.
DR KEGG; mah:MEALZ_0265; -.
DR PATRIC; fig|271065.3.peg.276; -.
DR HOGENOM; CLU_000022_69_2_6; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000008315; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF325; 3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE II FABF; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Reference proteome {ECO:0000313|Proteomes:UP000008315};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 1..405
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 406 AA; 43288 MW; 0414808BBE42A5DF CRC64;
MKRVVVTGMA AITPIGNDWA TVADNLKAQN TGIRRMDDWD KYNGLNTRLG GPVDFTRPAH
YSRKQVRGMG RVAMLATYAT ELALQDAGLL NDPVLKSGRT GVSYGSSSGS FDGLIDFTKM
LLNFDKGGLN ATSYIRMMGH TCPVNISLHF GVNGRIIPTS SACTSSSQGI GYAYEAIKHG
QQTVMIAGGS DELSASQAAV FDTLFATSLR NDEPDKSPRP FDRDRDGLVI GEGGGTFILE
EREHALSRGA TIHAEIVGFG TNCDGLHVTQ PDSTSMQVAM QLALQDSGLD PAAIGYVSAH
GTATELGDIA ESHATAAVLG SKIPISSMKS YTGHTLGACG SIEAWAAVRM MNEGWFHPTA
NLDAVDPKCA ELDYIQGAVR KLECDYLMSN NFAFGGINTS LIFKRV
//
