ID   G4SYM5_META2            Unreviewed;      1155 AA.
AC   G4SYM5;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:CCE23211.1};
GN   OrderedLocusNames=MEALZ_1523 {ECO:0000313|EMBL:CCE23211.1};
OS   Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS   B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylotuvimicrobium.
OX   NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE23211.1, ECO:0000313|Proteomes:UP000008315};
RN   [1] {ECO:0000313|Proteomes:UP000008315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC   {ECO:0000313|Proteomes:UP000008315};
RX   PubMed=22207753; DOI=10.1128/JB.06392-11;
RA   Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA   Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA   Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA   Trotsenko Y.A., Kalyuzhnaya M.G.;
RT   "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT   Methylomicrobium alcaliphilum 20Z.";
RL   J. Bacteriol. 194:551-552(2012).
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DR   EMBL; FO082060; CCE23211.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4SYM5; -.
DR   STRING; 1091494.MEALZ_1523; -.
DR   KEGG; mah:MEALZ_1523; -.
DR   PATRIC; fig|271065.3.peg.1563; -.
DR   HOGENOM; CLU_000022_23_0_6; -.
DR   Proteomes; UP000008315; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   CDD; cd05931; FAAL; 1.
DR   CDD; cd19531; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR040097; FAAL/FAAC.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   PANTHER; PTHR22754:SF32; DISCO-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR22754; DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008315}.
FT   DOMAIN          656..734
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1155 AA;  127515 MW;  2CB553800259E75F CRC64;
     MDLKIASVLP RQPGNANRYA RLIHVISFYE YGGYVLNDRP NFDSSVIDAP LLDGAISLTD
     ILQRRAVCHP HRTAYTFLDF GGPTPRSLTY GELNQEARQL AFQLHRMELR GERAVLLYPP
     GLDYIVAFYA CLYSGTIAVP AYPPSNNRHM PRLQAIIDDS KAKIILTTGQ VANSIRQFAG
     ATENLLDRRW VQTDTLETHD TGLWQASVLQ EKDLAFLQYT SGSTGNAKGV MISHGNLMAN
     QQLIQRRFGH DERSTVVGWL PLYHDMGLIG NVMQPLYCGA SAVLMSPMAF LEKPLRWLQA
     ISDYRAHTSG GPNFAYDLCT QKISRDELEA IDLGSWQLAF NGAEPVNPKT LERFSRTFAD
     CGFQRCAFYP CYGLAEATLL ATGGTKQSPL TIAAFDRAAL EDRTARPVAD NHPNAKQFVG
     CGAADSHAGQ DLRIVDPDNN EIYADGRIGE IWLSGPSIAQ GYWKNPETSQ KTFVNDTGGK
     RWLRTGDLGF INDGELFVSG RLKDLIIVRG RNYYPHDLEY AVESATDALN PASTVAFALA
     EDEAEKVIVL AELKRNRIRQ GDYQHEFAAI RARLTEECGI QAERIVLLKP GAILKTSSGK
     LRRSACRDLY VQQGFACIAV DALQAANDTT PPPVNVDKGT HERRLLRQAL LSMNCTHAID
     LLAGHLAIKA AELSGAAEDT IEPNHTLTGL GLDSLKAVEM KYFIDELLAV DMPITGLLGN
     ATLFDSALTA LNLAKTVGQE TPSLIDKDGQ GSNTAMSYNQ QALWTRAKIE SDEATLYHMP
     IALQIRGELD YPALDRALAE LHRRHSQLCR GFDLGADNRP ISFPLERLES SPVRTVCSDY
     VQQMKALDVL INKPFDLQHG PLLRCGIFSC SDDDHILAFC AHHLIVDFRS SRVLLAELQA
     LYAGYLNGIP ANLPLSQADY AEFVSWQRDY LNSEAAEQDL DYWRRQLAGE LPRLELPGYF
     VTEPTQASSA GMERLSIAAD TLIRLKNLAA EQHVTLYTLL LTVFKILLYR YSSQNDLIVG
     SPTFGRPLSR FADLVGYFVN PVALRSKPGG GLRFSEYLSA VNTVVLGALE HQHYPQTRII
     ENLRSEKGQG TLELYRIFFA LQDGSDPMAA ALAIGNAGIS LQWAGFEAVI CKLPNTAEEF
     DLAMLAAETG EGLSA
//