ID G4TNH4_SERID Unreviewed; 853 AA.
AC G4TNH4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
GN ORFNames=PIIN_06803 {ECO:0000313|EMBL:CCA72867.1};
OS Serendipita indica (strain DSM 11827) (Root endophyte fungus)
OS (Piriformospora indica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Sebacinales; Serendipitaceae; Serendipita.
OX NCBI_TaxID=1109443 {ECO:0000313|EMBL:CCA72867.1, ECO:0000313|Proteomes:UP000007148};
RN [1] {ECO:0000313|EMBL:CCA72867.1, ECO:0000313|Proteomes:UP000007148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11827 {ECO:0000313|EMBL:CCA72867.1,
RC ECO:0000313|Proteomes:UP000007148};
RX PubMed=22022265; DOI=10.1371/journal.ppat.1002290;
RA Zuccaro A., Lahrmann U., Guldener U., Langen G., Pfiffi S., Biedenkopf D.,
RA Wong P., Samans B., Grimm C., Basiewicz M., Murat C., Martin F.,
RA Kogel K.H.;
RT "Endophytic Life Strategies Decoded by Genome and Transcriptome Analyses of
RT the Mutualistic Root Symbiont Piriformospora indica.";
RL PLoS Pathog. 7:e1002290-e1002290(2011).
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCA72867.1}.
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DR EMBL; CAFZ01000187; CCA72867.1; -; Genomic_DNA.
DR AlphaFoldDB; G4TNH4; -.
DR STRING; 1109443.G4TNH4; -.
DR eggNOG; KOG1005; Eukaryota.
DR HOGENOM; CLU_001996_0_1_1; -.
DR InParanoid; G4TNH4; -.
DR OMA; GHLEHEY; -.
DR OrthoDB; 55913at2759; -.
DR Proteomes; UP000007148; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.10.2210; -; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR Gene3D; 1.10.357.90; -; 1.
DR Gene3D; 3.10.10.20; -; 1.
DR Gene3D; 3.30.70.2630; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR InterPro; IPR049139; TERT_C.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR Pfam; PF21399; TERT_C; 1.
DR PRINTS; PR01365; TELOMERASERT.
DR SMART; SM00975; Telomerase_RBD; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000007148};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061,
KW ECO:0000313|EMBL:CCA72867.1};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 339..660
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 853 AA; 98204 MW; C6C8D4FEF9321A3E CRC64;
MFYASAKHLS HIKLRTGLPA KHILNRISSG EIRSISVRRD REWDGGDDIR LLAKYIFPRQ
YGLHNVFTCE KARGPWPFKD YTVRDQEIHS QGTKKTPKRL QSVLPLLGRL LNGHKKLDYD
ATLSRTCPSK LKMTANSTVD SSVILELMSE STQPSSTQLF APDGHQINTS APPIHKQTSP
KPRFAEFMCS HREVISFVLA ITSSVIPNEL WGSAENYKHV SKRIAEFIDL RRHESLTLHS
VAQNVKVLDF AWAFPEHNGN KVSKRPPSDA NKARELVDEF LYWYFDSFLL PLLKTTFYCT
ESSAFKSRVL YFRQDDWLRL TEPLLDKLCS ETFIKVPLNE VQQDIEGRKL GYGQVRLLPK
ETGVRPIVNL GRKLAVKERP KDPGFSINQM LQATFQILTF EKQRNPSLQG YSVTDSTGIY
TKLKQFKERH RSPDGRMPKL YFVKLDVRAC FDTIDQGLLL EIIQRIIQEE NYLLQRYTQV
YPMVGKIQKR FTGYAIPEDE TLDVLTLASK LATIVRHTVF TDQVVQTFEE RDEVLSLLEE
HITSNIVKIR GEFYKQQVGI PQGSVLSTIL CNFFYGDLEA SNPFSFVNDP SHVLLRYMDD
YLLVSTSLSA AHQFLEMMKQ GHPQYGCFIA EDKTITNFEH IAAGTVVREE NYMPWCGLHV
NLQSLDVSID FTRFQGKNIL NALSVDSSHR PAASFKYKIM RTARDRCHLL FLDVNFNHRF
TVLCNVFENF LLVAIKTLHY LQQWQTDLAK HHQFICSSIK EIIAYISLVI RVRTSGPLAR
TLGSKCDIPT NLMSWLGYQA FFHIFASKKP HLGRISTALL VEMRKSQYRA LRDTSRYRRV
IQRGKQAISS VYI
//
