ID G4UNW3_NEUT9 Unreviewed; 442 AA.
AC G4UNW3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=ApbA-domain-containing protein {ECO:0000313|EMBL:EGZ72344.1};
GN ORFNames=NEUTE2DRAFT_150780 {ECO:0000313|EMBL:EGZ72344.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ72344.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ72344.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; GL891236; EGZ72344.1; -; Genomic_DNA.
DR AlphaFoldDB; G4UNW3; -.
DR STRING; 510952.G4UNW3; -.
DR eggNOG; ENOG502QPT5; Eukaryota.
DR HOGENOM; CLU_031468_9_0_1; -.
DR OMA; RKEPFQV; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008513}.
FT DOMAIN 72..242
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 281..425
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 442 AA; 49025 MW; 6B2D751324243D03 CRC64;
MVRFVTNTST TTRLLAQSVP KNGVTLPPWL HNITQSISAA PKLYAWTPEN LPNSRNNGQF
QSATPKDLQR RIFILGIGNL GRLYANSLGK LGEEVPVTLV LHRKSLLEHW VSEPGIELTR
HGVTEKMSSF DVEWWTEEAP THGPVREVCD GHKIANLLVA TKAPDALPQV DRLRRYLDGN
STVGFVQNGM NKLWPPYGAI YSEHRFPPRQ HPNWLVCVTT HGVFSLGTFK SVHAAPADIA
MGLVLPNPNT AHAADYLMEQ IGRAPELEAR KVPRNALWVL QLEKLIINSL INPLTAVIRC
MNGHLFDQPA PELKKLMDIL VDEASQILQA LAQHPSSKDI LSGADSAPDA DLSKEALVER
FSAVRLNAML QRVGEKVKDN RSSMCQDVMA GKQTEVREFN GWLVQMAEYL GLEAPNHKKL
CELVEGGVIG ETSLLEAYFG KK
//
