ID G4USK7_NEUT9 Unreviewed; 322 AA.
AC G4USK7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:EGZ70583.1};
GN ORFNames=NEUTE2DRAFT_145097 {ECO:0000313|EMBL:EGZ70583.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ70583.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ70583.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
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DR EMBL; GL891247; EGZ70583.1; -; Genomic_DNA.
DR AlphaFoldDB; G4USK7; -.
DR STRING; 510952.G4USK7; -.
DR eggNOG; KOG1577; Eukaryota.
DR HOGENOM; CLU_023205_0_3_1; -.
DR OMA; IGTGTRW; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0016652; F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19120; AKR_AKR3C2-3; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044494; AKR3C2/3.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008513}.
FT DOMAIN 41..302
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 81
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 137
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 106
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 322 AA; 35681 MW; 8BC836F6FB5B988F CRC64;
MNSATSNFEV DATGVSPKQI HNLIPSLKLA DGNEIPMLGY GLGTANYKSG DSADTISEPI
VNATLTALNA GYTHLDGAEV YGNEVELGRA IAQSKLPRSS LYITTKTIVR AGDTVTQSFN
RSLEKLGLDY VDLYLLHSPF FAKNPEELQA AWREMEKIKD SGMAKSIGVS NFLISHLQTL
FDIPGGLQYP PVVNQIEYHP YLQHVVEGED LVAFCREKHI ALEAYSPLTA ITKARPGPVD
PIYTQLAKKY GVSEAEIAFR WCLDQGIVTL TTSSNEERLK GYLKKLPSFK LTPKEVEDIA
SAGKEKHYRV WWTEEFAADD RH
//
