ID   G4V4S0_AMYOR            Unreviewed;       408 AA.
AC   G4V4S0;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Putative C-3 methyltransferase {ECO:0000313|EMBL:CCD33145.1};
DE            EC=2.1.1.- {ECO:0000313|EMBL:CCD33145.1};
GN   Name=vcaC {ECO:0000313|EMBL:CCD33145.1};
OS   Amycolatopsis orientalis (Nocardia orientalis).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=31958 {ECO:0000313|EMBL:CCD33145.1};
RN   [1] {ECO:0000313|EMBL:CCD33145.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC19795 {ECO:0000313|EMBL:CCD33145.1};
RA   Woertz T., Dietz S., Zerbe K., Robinson J.A.;
RT   "The vancomycin biosynthetic gene cluster.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HE589771; CCD33145.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4V4S0; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 6.10.250.3100; -; 1.
DR   Gene3D; 6.20.50.110; Methyltransferase, zinc-binding domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR013630; Methyltransf_Zn-bd_dom_put.
DR   InterPro; IPR038576; Methyltransf_Zn-bd_dom_put_sf.
DR   InterPro; IPR013691; MeTrfase_14.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43861:SF5; BLL5978 PROTEIN; 1.
DR   PANTHER; PTHR43861; TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF08421; Methyltransf_13; 1.
DR   Pfam; PF08484; Methyltransf_14; 1.
DR   Pfam; PF13489; Methyltransf_23; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:CCD33145.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CCD33145.1}.
FT   DOMAIN          7..66
FT                   /note="Methyltransferase putative zinc binding"
FT                   /evidence="ECO:0000259|Pfam:PF08421"
FT   DOMAIN          246..403
FT                   /note="C-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF08484"
SQ   SEQUENCE   408 AA;  45335 MW;  C21456E57781243D CRC64;
     MSTTSQCRIC DGTVTEFIDF GRQPLSDAFV VPGDEKKEFF FRLATGICES CTMVQLMEEV
     PRDLMFHEAY PYHSSGSAVM RTHFHDLAKR FLTTELTGED PFIVELGCND GIMLKAIAEA
     GVRQLGVEPS GGVADLAAAK GIRVRKDFFE EATAADIRKN DGPADVIYAA NTLCHIPYMD
     SILKGVTTLL GPNGVFVFED PYLGDIVERT SFDQIYDEHF FFFTARSVQE MARRNGLELV
     DVERIPVHGG EVRYTLALAG ARKPTEAVAE LLAWEAERKL SEFATLERFA ANVKKVKEDL
     IALLTKLRAE GKRVVGYGAT AKSATVTNFC GITPDLVEFI SDTTPAKQGK LSPGQHIPVR
     EYREFADDHP DYALLFAWNH ADEIMNAEQA FRDAGGQWIR YVPNVHVS
//