ID G4VDU5_SCHMA Unreviewed; 533 AA.
AC G4VDU5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=RNA methyltransferase {ECO:0000256|RuleBase:RU367087};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU367087};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_021750.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_021750.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_021750.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361, ECO:0000256|RuleBase:RU367087}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_018649656.1; XM_018795332.1.
DR AlphaFoldDB; G4VDU5; -.
DR STRING; 6183.G4VDU5; -.
DR EnsemblMetazoa; Smp_021750.1; Smp_021750.1; Smp_021750.
DR GeneID; 8343439; -.
DR KEGG; smm:Smp_021750.1; -.
DR WBParaSite; Smp_021750.1; Smp_021750.1; Smp_021750.
DR CTD; 8343439; -.
DR eggNOG; KOG2899; Eukaryota.
DR HOGENOM; CLU_038418_0_0_1; -.
DR InParanoid; G4VDU5; -.
DR OrthoDB; 1130801at2759; -.
DR PhylomeDB; G4VDU5; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR039772; Bin3-like.
DR InterPro; IPR010675; Bin3_C.
DR InterPro; IPR024160; BIN3_SAM-bd_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12315:SF0; 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME; 1.
DR PANTHER; PTHR12315; BICOID-INTERACTING PROTEIN RELATED; 1.
DR Pfam; PF06859; Bin3; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51515; BIN3_SAM; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU367087};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00848};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367087}.
FT DOMAIN 141..435
FT /note="Bin3-type SAM"
FT /evidence="ECO:0000259|PROSITE:PS51515"
FT REGION 105..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 60560 MW; 60B1A761843BA63D CRC64;
MRHLRGSASY SREHRVSARS YCFPQPRGVA SRHFGNWYPH PTVNRPPGVR HDVRLITSFA
NAPGLLGSQI PLLTHLAIRP HHINRVRAKR DNSFTRSRFL NRRKRSVRAS KNTLNPSDPL
NLQDLMKETE RRRVEGLSPL RGDSRMNTPA ASVAGDVDCG SPQNHGIQTS SASKDSGSPR
LSGRKLDCHS KRQSHRLIRR RPMRASKCYT VGRCIRGFLP TTGNYCDYYR RRDPNDRLPY
LMPEWFVGKD VADYGCHNGT LTFGVLEKFP EVKKIDAFDC DAELIANAQS MQREKLRWDI
ESNVRYEKIN FQVANWIDES TTNDEPEYDT IMAFSVTKWI HLNHGDPGLM RFFRRAFNRL
KPGGHLILEP QPKSSYKRTR LTAKHRSIYE TLKINPSNLE PLLVDLGFSY FDTIKDPRPN
EPFRRKIILC SKSYGATPAS IRNDFRSEVH NWQSFNSPHS PHGREPPPVC YLPQTPVYNV
GTPFTTGSSP MSRHICASST VLSPTVLPSV SPLIAVVDPV STPTCEPDST SNC
//
