ID G4XFL9_9CALI Unreviewed; 195 AA.
AC G4XFL9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=RNA-dependent RNA polymerase {ECO:0000313|EMBL:AEP22341.1};
DE Flags: Fragment;
OS Norovirus Hu/GII.8/A155/Limbe/2009/Cameroon.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
OX NCBI_TaxID=1087436 {ECO:0000313|EMBL:AEP22341.1};
RN [1] {ECO:0000313|EMBL:AEP22341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A155/2009CMR {ECO:0000313|EMBL:AEP22341.1};
RX PubMed=22012721; DOI=10.1002/jmv.22243;
RA Ayukekbong J., Lindh M., Nenonen N., Tah F., Nkuo-Akenji T., Bergstrom T.;
RT "Enteric viruses in healthy children in Cameroon: viral load and genotyping
RT of norovirus strains.";
RL J. Med. Virol. 83:2135-2142(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-
CC diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00001491};
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DR EMBL; JF802498; AEP22341.1; -; Genomic_RNA.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR Pfam; PF00680; RdRP_1; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:AEP22341.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 6..147
FT /note="RNA-directed RNA polymerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00680"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEP22341.1"
SQ SEQUENCE 195 AA; 22210 MW; 85017BCB13A533CA CRC64;
LTLSAMSEVS GLSPEVVQAN SCFSFYGDDE IVSTDINLDP EKLTRKLREY GLVPTRPDKT
EGPLVITQDL NGLTFLRRTI VRDPAGWFGK LDRDSILRQL YWTRGPNHEN PFESMIPHSQ
RATQLMALLG EASLHGPQFY KKVSKMVINE IKSGGLEFYV PRQEAMFRWM RFSDLSTWEG
DRNLAPENVN EDGVE
//
