ID   G4XGK3_ECOLX            Unreviewed;       202 AA.
AC   G4XGK3;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126};
DE   Flags: Fragment;
GN   Name=aadA2 {ECO:0000313|EMBL:AEP16473.1};
OS   Escherichia coli.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562 {ECO:0000313|EMBL:AEP16473.1};
RN   [1] {ECO:0000313|EMBL:AEP16473.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DJ30-3 {ECO:0000313|EMBL:AEP16473.1};
RA   Su H.;
RT   "Class 1 and 2 integrons, sul resistance genes and antibiotic resistance in
RT   Escherichia coli isolated from Dongjiang River, Guangdong Province, South
RT   China.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070};
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DR   EMBL; JF806491; AEP16473.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4XGK3; -.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Transferase {ECO:0000313|EMBL:AEP16473.1}.
FT   DOMAIN          24..93
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          149..202
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
FT   NON_TER         202
FT                   /evidence="ECO:0000313|EMBL:AEP16473.1"
SQ   SEQUENCE   202 AA;  22665 MW;  98541B14182577A5 CRC64;
     MTIEISNQLS EVLSVIERHL ESTLLAVHLY GSAVDGGLKP YSDIDLLVTV AVKLDETTRR
     ALLNDLMEAS AFPGESETLR AIEVTLVVHD DIIPWRYPAK RELQFGEWQR NDILAGIFEP
     AMIDIDLAIL LTKAREHSVA LVGPAAEEFF DPVPEQDLFE ALRETLKLWN SQPDWAGDER
     NVVLTLSRIW YSAITGKIAP KD
//