ID   G4XI19_HBV              Unreviewed;       478 AA.
AC   G4XI19;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AEQ33718.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AEQ33718.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AEQ33718.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HBV31 {ECO:0000313|EMBL:AEQ33718.1};
RX   PubMed=22012717; DOI=10.1002/jmv.22246;
RA   Reis L.M., Soares M.A., Franca P.H., Soares E.A., Bonvicino C.R.;
RT   "Clonal analysis of hepatitis B viruses among blood donors from Joinville,
RT   Brazil: evidence of dual infections, intragenotype recombination and
RT   markers of risk for hepatocellular carcinoma.";
RL   J. Med. Virol. 83:2103-2112(2011).
RN   [2] {ECO:0000313|EMBL:AEQ33718.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HBV31 {ECO:0000313|EMBL:AEQ33718.1};
RA   Reis L.M.W., Soares M.A., Franca P.C., Soares E.A.J.M., Bonvicino C.R.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JF815635; AEQ33718.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          165..408
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEQ33718.1"
FT   NON_TER         478
FT                   /evidence="ECO:0000313|EMBL:AEQ33718.1"
SQ   SEQUENCE   478 AA;  53256 MW;  43C0CC056F0DC8C3 CRC64;
     GAESFHQQSS GILSRPPVGS SLQSKHLKSR LGLQSQQGHL ARRQQGRSWS IRAGFHPTAR
     RPFGVEPSGS GHTTNFASKS ASCLHQSPVR KAAYPAVSTF EKHSSSGHAV EFHNLPPNSA
     RSQSERPVFP CWWLQFRNSK PCSDYCLSLI VNLLEDWGPC AEHGEHHIRT PRTPSRVTGG
     VFLVDKNPHN TAESRLVVDF SQFSRGNYRV SWPKFAVPNL QSLTNLLSSN LSWLSLDVSA
     AFYHLPLHPA AMPHLLVGSS GLSRYVARLS SNSRIINHQH GTMPNLHDSC SRNLYVSLLL
     LYQTFGRKLH LYSHPIILGF RKIPMGVGLS PFLLAQFTSA ICSVVRRAFP HCLAFSYMDD
     VVLGAKSVQH LESLFTAVTN FLLSLGIHLN PNKTKRWGYS LNFMGYVIGC YGSLPQEHIV
     QKIKECFKKL PINRPIDWKV CQRIVGLLGF AAPFTQCGYP ALMPLYACIQ SKQAFTFS
//