ID G5ALU0_HETGA Unreviewed; 864 AA.
AC G5ALU0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 5 {ECO:0000313|EMBL:EHA98000.1};
GN ORFNames=GW7_17597 {ECO:0000313|EMBL:EHA98000.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98000.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA98000.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH165892; EHA98000.1; -; Genomic_DNA.
DR AlphaFoldDB; G5ALU0; -.
DR STRING; 10181.G5ALU0; -.
DR eggNOG; KOG1419; Eukaryota.
DR InParanoid; G5ALU0; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..270
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 380..567
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 345..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 96160 MW; D46A3EB214492EE7 CRC64;
MSLLGKPLSY SSGQSCRRNA KYRRVQNYLY NVLERPRGWA FVYHAFVFLL VFGCLILSVF
STIPEHTKLA SSCLLILEFV MIVVFGLEFI IRIWSAGCCC RYRGWQGRLR FARKPFCVID
TIVLIASIAV VSAKTQGNIF ATSALRSLRF LQILRMVRMD RRGGTWKLLG SVVYAHSKEL
ITAWYIGFLV LIFSSFLVYL VEKDANKEFS TYADALWWGT ITLTTIGYGD KTPLTWLGRL
LSAGFALLGI SFFALPAGIL GSGFALKVQE QHRQKHFEKR RNPAANLIQC VWRSYAADEK
SVSIATWKPH LKALHTCSPT KKEQGETASS KLCSNKQKLF RMYTSRKQSQ KLSFKERVRM
ASPRGQSIKS RQASVGDRRS PSTDITAEGS PTKVQKSWSF NDRTRFRPSL RLKSSQPKPV
IDADTALGTD DVYDEKGCQC DVSVEDLTPP LKTVIRAIRI MKFHVAKRKF KETLRPYDVK
DVIEQYSAGH LDMLCRIKSL QTRVDQILGK GQITSDKKSR EKITAEQETT DDLSMLGRVV
KVEKQVQSIE SKLDCLLDIY QQVLRKGSAS ALTLASFQIP PFECEQTSDY QSPVDSKDLS
SSAQNSGCLT RSASANISRG LQFILTPNEF SAQTFYALSP AMHSPVTQVP MSQSDSSTVA
ASNIANQITT APKPVAPTTL QIPPPLPAIK HLPRPETLHP NPTGLQESIS DATTCLVSSK
ENIQVAQSNL TKDRSLRKSF DTGGETLLSI LPTVSKDLGK SLSVQNLIRS TEELNLQLSG
SESSGSRGSQ DFYPKWRESK LFITDEEVCA EETETDTFDG TPQPAKEAAF PTDSLRTGRS
RSSQSICKAG ESSDALSLPH VKLK
//
