ID G5AQN3_HETGA Unreviewed; 681 AA.
AC G5AQN3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=MCM domain-containing protein 2 isoform a {ECO:0000313|EMBL:JAN97562.1};
GN Name=MCMDC2 {ECO:0000313|EMBL:JAN97562.1};
GN ORFNames=GW7_03617 {ECO:0000313|EMBL:EHA99343.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99343.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA99343.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN97562.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:JAN97562.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH166501; EHA99343.1; -; Genomic_DNA.
DR EMBL; GEBF01006070; JAN97562.1; -; Transcribed_RNA.
DR RefSeq; XP_004842151.1; XM_004842094.1.
DR AlphaFoldDB; G5AQN3; -.
DR STRING; 10181.G5AQN3; -.
DR Ensembl; ENSHGLT00100015819; ENSHGLP00100015648; ENSHGLG00100011553.
DR GeneID; 101711255; -.
DR KEGG; hgl:101711255; -.
DR CTD; 157777; -.
DR eggNOG; KOG0480; Eukaryota.
DR InParanoid; G5AQN3; -.
DR OMA; AEKMIHG; -.
DR OrthoDB; 5294704at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000012730; Expressed in testis.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF75; MINICHROMOSOME MAINTENANCE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR SMART; SM00350; MCM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 541..621
FT /note="MCM AAA-lid"
FT /evidence="ECO:0000259|Pfam:PF17855"
SQ SEQUENCE 681 AA; 76216 MW; 9B21D1E59E40E640 CRC64;
MSNLKMKEAA LIYLDRSRGL QKFIDDCKYY NDSKQSYAVY RFNILINPSD VLELDAELGN
HILHHPLKAA QVFQSVCFIA VKTLSLIAQL QTETQINIVL KLTHLPPLPS YILDLCEFPL
DYTSQRFYMM QGIVIAMTTI TKYTQGARFL CSEEACPLSK GFQYIRVHMP GATESATVRN
DFLCNLCSSS LQEDRKFRVL GDKQIVEIIT PKALCAFQGY SKNQAFRFQS FKVFLRDELV
NKMNIGNEYK IIGIPACVKS SQTAICIEAN SIILCNPKVS SGISENFNCL LSLTSGSCWK
FTAILANIFA SQIVPPGTYN LLKLCLLMSL VQTSDSKKEL ENSLDILIIT SDTLLVERLL
NFSVNLISRG IHHPVSTEIF PTLSRNKYGT GAFSIQAGSA LLAKGGICFI GDLCSHKKDK
LEQLQSVLES RSITVYIPGK KFGDDIDQQM TFPVQCSFWS FVDMDSSSKR NAQKTNTLIG
QMDCSLIPAN FVEAFGLLIN CNESSPCHPL LPTVQHTLKK ATDSKGLLHL ASKQFTTEDF
EKLLIFAKNL NVEFSLEAER MIHGYYLASR RIRTDSMYGS KLSASALKYL VSLSEAHARL
NLRNKVLKED VLIAALLSET SLTLKYGATA FGVAPNAVFP FELYNEEYLE QRDLYLTQCQ
QQLQQFIATY GPGIALFSSD E
//
