ID   G5ARV8_HETGA            Unreviewed;       568 AA.
AC   G5ARV8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=RING finger protein 220 {ECO:0000313|EMBL:EHA99772.1};
GN   ORFNames=GW7_00348 {ECO:0000313|EMBL:EHA99772.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99772.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHA99772.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
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DR   EMBL; JH166648; EHA99772.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5ARV8; -.
DR   STRING; 10181.G5ARV8; -.
DR   eggNOG; ENOG502QR1N; Eukaryota.
DR   InParanoid; G5ARV8; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd16563; RING-HC_RNF220; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031824; RNF220_mid.
DR   InterPro; IPR040178; RNF220_RING.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13459:SF3; E3 UBIQUITIN-PROTEIN LIGASE RNF220; 1.
DR   PANTHER; PTHR13459; UNCHARACTERIZED; 1.
DR   Pfam; PF15926; RNF220; 2.
DR   Pfam; PF13923; zf-C3HC4_2; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          516..555
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          277..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  62920 MW;  DD8A3C0EB61FDCB8 CRC64;
     MDLHRAAFKM ENSSYLPNPL ASPALMVLAS TAEASRDASI PCQQPRPFGV PVSVDKDVHI
     PFTNGSYTFA SMYHRQGGVP GTFANRDFPP SLLHLHPQFA PPNLDCTPIS MLNHSGVGAF
     RPFASTEDRE SYQSAFTPAK RLKNCHDTES PHLRFSDADG KEYDFGTQLP SSSPGSLKVD
     DTGKKIFAVS GLISDREASS SPEDRNDRCK KKAAALFDNQ APICPICQVL LRPSDLQEHM
     EQELEQLAQL PTSKNSLLKD AMAPGTPKSL LLSASIKREG ESPTASPHSS ATDDLHHSDR
     YQETLECRAR RAQRATARIG KMKRRKQDEG QREGSCIAED DAVDIEHENS NRFEEYEWCG
     QKRIRATTLL EGGFRGSGFV MCSGKENPDS DADLDVDGDD TLEYGKPQYT EADVIPCTGE
     EPGEAKEREA LRGAVLKQVG GPPSTRITPE FSKWASDEMP STSNGESSKQ EAMQKTCKNS
     DIEKITEDST VTTFEALKAR VRELERQLSR GDRYKCLICM DSYSMPLTSI QCWHVHCEEC
     WLRTLGAKKL CPQCNTITAP GDLRRIYL
//