ID G5AV22_HETGA Unreviewed; 349 AA.
AC G5AV22;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN ORFNames=GW7_18147 {ECO:0000313|EMBL:EHB00883.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB00883.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB00883.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|ARBA:ARBA00005771, ECO:0000256|RuleBase:RU361155}.
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DR EMBL; JH167046; EHB00883.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AV22; -.
DR STRING; 10181.G5AV22; -.
DR eggNOG; KOG1584; Eukaryota.
DR InParanoid; G5AV22; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR11783:SF8; SULFOTRANSFERASE 2A1; 1.
DR PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 98..341
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
SQ SEQUENCE 349 AA; 40505 MW; 9BC5EC8E13569A02 CRC64;
MQDPGGFLGG TLLDIAPGNS AQVCGSSTPE AVATLLIKGG NVRCPRICLL MYLKRYTRHK
ELIIMADVYG WFEGIAFPLA YFNLEVLREA RDTFVVKDED IIMVTYPKSG THWLSEIICL
IHSKGDPKWI QSVPIWERTP WIETQIGYNS LKDKEDPRIW TTHLPIQLFP KSFFSSKAKV
IYGIRNPRDV LVSGYFFWRK MSIAQQAETL QEYMEWFLQG NVIYGSWFEH VRGWLSMRDS
ENVLVVSYED LTKDPRCTVE KICKFLGKKL KPEEIDLVLK YSCFQFMKEN KMSNSTIFPD
EYLSEDFSFQ RKGVAGDWKN HFTVAQAEAF DEIYQKKMAG FPPKLFPWE
//
