ID   G5AX14_HETGA            Unreviewed;       889 AA.
AC   G5AX14;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=General transcription factor 3C polypeptide 3 {ECO:0000313|EMBL:EHB01575.1};
GN   ORFNames=GW7_11604 {ECO:0000313|EMBL:EHB01575.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB01575.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB01575.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
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DR   EMBL; JH167290; EHB01575.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5AX14; -.
DR   STRING; 10181.G5AX14; -.
DR   eggNOG; KOG2076; Eukaryota.
DR   InParanoid; G5AX14; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; IEA:InterPro.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR039340; Tfc4/TFIIIC-102/Sfc4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR23082:SF0; GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3; 1.
DR   PANTHER; PTHR23082; TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED; 1.
DR   Pfam; PF13181; TPR_8; 3.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50005; TPR; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          219..252
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          459..492
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          814..847
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..116
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   889 AA;  101343 MW;  1DC8121139EEFE76 CRC64;
     MSGFSPELID YLEGKISFEE FERRREERKT REKKARSRAG LQEEGKLSAE ENADDSEAPS
     SSGINSSKSH VRDVSEGETS DGVSKSVQKV FDSMLGETED DEEEEEEEEE GEEMLEQPTA
     GEVFALELVL NRETKKMMKE KRPRSKLPRA LRGLMGEANI RFARGKREEA ILMCMEIIRQ
     APLAYEPFST LAMIYEDQGD MEKSLQFELI AAHLNPSDTE EWVRLAEMSL EQDNIKQAIF
     CYTKALKYEP TNIRFLWERS SLCEQMGDHK MAMDGYRRIL NLLPASDGER FMQLARDMAK
     SYYEASDSAS AINIIEEAFS KHQALVSMED VNIAAELYIS NKQYDRALEV ITDFSGIVLE
     KQTLEEDGPS EENKACDGIT CAVPEGVPID IMVKLMVCLV HLHILEPLNP LLTTLVEQNP
     EDMGDLYLDV AEALLDIGEY SSALPLLSAL VCSERYSLAV VWLRHAECLK ALGYMERAAE
     SYSKVVDLAP LHLDARISLS TLQQQLGRPE KALEALEPMY DPDTLAQDAN AAQQELKLLL
     HRSTLLFSQG KMRGYVDTLL TMLAMLLKVA MNRAQVCLIS SSKSGERHLY LMKVSRDKIS
     DSNDQESANC DAKAIFAVLT SVLPKDDWWN LLLKAIYSLC DLSRFEEAEL LADSSLEYYS
     FYDDRQKRKE LEYFGLSAAI LDKNFRKAYN YIRIMVMENV NKPQLWNIFN QVTMHSQDVR
     HHRFCLRLML KNPDNHALCV LNGHNAFVSG SFKHALAQYI QAFRARRDEP LYNMCIGLTF
     IHMASQKYVL KRHALIVQGF AFLNRYLSLR GRCQESLYNL GRALHQLGLT HLAIHYYQEA
     LELPPLEAEG IEAEQVDLRR DIAYNLALIY QSSGNLLMAR YLLFTYCTI
//