ID G5AX24_HETGA Unreviewed; 217 AA.
AC G5AX24;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Pre-mRNA-splicing factor 38A {ECO:0000256|ARBA:ARBA00018053, ECO:0000256|RuleBase:RU367025};
GN ORFNames=GW7_04516 {ECO:0000313|EMBL:EHB01585.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB01585.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB01585.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Involved in pre-mRNA splicing as a component of the
CC spliceosome. {ECO:0000256|ARBA:ARBA00002609,
CC ECO:0000256|RuleBase:RU367025}.
CC -!- SUBUNIT: Component of the spliceosome B complex.
CC {ECO:0000256|RuleBase:RU367025}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367025}.
CC -!- SIMILARITY: Belongs to the PRP38 family.
CC {ECO:0000256|ARBA:ARBA00006164, ECO:0000256|RuleBase:RU367025}.
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DR EMBL; JH167296; EHB01585.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AX24; -.
DR STRING; 10181.G5AX24; -.
DR InParanoid; G5AX24; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; IEA:UniProtKB-UniRule.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR InterPro; IPR005037; PRP38.
DR PANTHER; PTHR23142:SF1; PRE-MRNA-SPLICING FACTOR 38A; 1.
DR PANTHER; PTHR23142; UNCHARACTERIZED; 1.
DR Pfam; PF03371; PRP38; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU367025};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|RuleBase:RU367025};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367025};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|RuleBase:RU367025}.
FT REGION 167..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..186
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 217 AA; 25883 MW; 78EEA7C4E65EBB3B CRC64;
MANRTVKDAH SIRGTNPQYL VEKIIRTRIY ESKYWKEECF GLTAELVVDK AMELRFVGGV
YGGNIKPTPF LCLILKMFQI QPEKDIIVEF IKNEDFKYAR MLGSLYMRLT GTAIDCFKYL
EPLYNDYWKI KSQNRNGEFE LMHVDEFIDE LLHKRYLLEE AERLEPQVSA LEEDMEDVES
SEEKEEEDEK LERVPSPDHR WRRYRDLDKP RHSPTLC
//
