ID G5B1A8_HETGA Unreviewed; 1704 AA.
AC G5B1A8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
GN ORFNames=GW7_10657 {ECO:0000313|EMBL:EHB03069.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03069.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03069.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
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DR EMBL; JH167923; EHB03069.1; -; Genomic_DNA.
DR STRING; 10181.G5B1A8; -.
DR eggNOG; KOG1037; Eukaryota.
DR InParanoid; G5B1A8; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd17726; BRCT_PARP4_like; 1.
DR CDD; cd01437; parp_like; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 1.20.142.10; Poly(ADP-ribose) polymerase, regulatory domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR031273; PARP4.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
DR InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46530; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR PANTHER; PTHR46530:SF1; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF47587; Domain of poly(ADP-ribose) polymerase; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS51060; PARP_ALPHA_HD; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU362114};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362114}.
FT DOMAIN 1..94
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 241..369
FT /note="PARP alpha-helical"
FT /evidence="ECO:0000259|PROSITE:PS51060"
FT DOMAIN 368..572
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT DOMAIN 606..734
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 875..1045
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1285..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1704 AA; 190572 MW; 3B3949005783702B CRC64;
MTVGIFANCT FCLRVKYLPH QQKKKLQTNI KENGGKISFS LNPQCTHVIL DNADALSQYQ
LNYFQKNHIH TATPDFIWQS VKERKLLDLK DYDPAESQDI VPPPDHKMSY SEVKTDDLTL
DIAPEEEIVE ITEFCAENVE IPYFSQEFEI AKYNTLEKGG ADRGQETVVV ELQCAQEPGD
SPFLISAHFL LADGMQTRRE FTVKKTSADA SEYYEYYIEE LKKQGFLLRE HFTLEATQLA
SEKLQALLLE EVINSSTLSQ EVSSLVEMIW AEAQGHLEHI LLKPMNKISL NDVSKAEGIL
LLVKTALKNG ETTEQLQKMM TEFYRLIPHK QAATKDINLR LLAKKEDLCQ LIRDMVNVCE
THLSKPNPPS LAKYQALRCK IEHVEQNTEE FLRIRKEILQ NNHSETPVDI LQIFRVGKVN
EATEFLSKLG NVRSLLHGSP VQNIVGILSR GLLLPKLVED RGVQRTDIGN LGSGIYFSDS
LSTSIKYSPP AETDGSRFLI ICDVALGKCV DLFKKDFSLT DAPLGYDSVH GVSQTASVPT
DFEDDEFVVY KTNQVKMKYI IKFCMAGDQM KDFHPQDYSE LEGYRPEFLN TLRIDDYQLP
DPKPSSSVKA GLQDASGNLV PLESVHIKGR IIDFVAQVIV FQTYTNQSHV PIEAKYIFPL
DDKAAVCGFE AFINGKHIVG EIKEKEEAQR EYRAAVSQGH GAYLMDQAAP DVFTVSVGNL
PPKAKVLIKI TYITELSIRG PVAVFFMPAS VAPWQQDKAL NENLQDAIEK ICIKETGTKQ
SFSLTVCIEM PYVIDFISSD THELKQKRTD CRAVISTMEG STLDSNGFSL HIGLSNAYLP
RMWVEKHPEK ESEACMLVFQ PDLDATLPGP ANKNEVVICL DCSNSMEGVT FTQAKQIALY
ALSLVGEEQK VNVVQFGTSY KELFSYPKHI TNSNVPTEFI KSATPTMGNT DFWKTLRYLG
LLYPSQGVRN VLLISDGHLQ NESLTLKLVK RNVLHTRLFT CGTGPTANRH VLRNLAQCGA
GVFEYFNSRS EHSWKKQIED QMNRLHSPSC HSVSIKWQQL SADAQEPLQA PAQVPSLFHN
DRLLVYGLIS HCMQATLCAL IQEKEICSMV STTELQKTTG TMIHKLAARA LIRDFEDGIL
HKDEANHEMK KQIMKSLIIK LSKENSLITQ FTSFVAIEKR DGNELPFPNT PNILELIDKE
DVDFLPYMSW QEEQEEADMM QPLSAFPEWD EKLQLKGLAK RRLWLSTPKD SEDFEEMVLG
MEEVVQPVAL ESQSRDVENL LDLAEMDSPR QDGFKAPSET ASRKQKAAST SLFAPPLLAV
PNTHSFSFSS SNVRPQAFGF SAPPRQFGQS RSSHGLELDA VPSISLKGLP HLSKPSSLLD
RRAPLAGSMG SAQFDPCKFY PGSENSLFPV VSSELAFPRP PPFFSLGSTT GIMSGGPYIP
HRPSLQSSLC ARGAHYSLTE PLLEEASCQP DSSALCSAPP VPKAQLSRSK EAKGKNIGGS
LFGTESNKTP ARILAYKSLK RKKKSVMSLN SPLEDEGGTV HQASGKNSVL WAALFSLQTK
DGFWKLTPEL GQILNLNTNV LHDFLEQKGI RSLGVKGREC LLDLIATLLV LQFLRTKLEQ
EELIFKSLMK LDDPYISSCV VIPWDCEAVK KASAWARRME RRYASICHRL ELGEDWDTAT
KQLLGIQPPA SSSSLHCVLY PGQG
//
