ID G5B1T1_HETGA Unreviewed; 1927 AA.
AC G5B1T1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Lactase-phlorizin hydrolase {ECO:0000313|EMBL:EHB03242.1};
GN ORFNames=GW7_18616 {ECO:0000313|EMBL:EHB03242.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03242.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03242.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH168039; EHB03242.1; -; Genomic_DNA.
DR STRING; 10181.G5B1T1; -.
DR eggNOG; KOG0626; Eukaryota.
DR InParanoid; G5B1T1; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 4.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR018120; Glyco_hydro_1_AS.
DR InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR10353:SF36; KLOTHO (MAMMALIAN AGING-ASSOCIATED PROTEIN) HOMOLOG; 1.
DR Pfam; PF00232; Glyco_hydro_1; 4.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 4.
DR PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 2.
DR PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 3.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|RuleBase:RU004468};
KW Hydrolase {ECO:0000256|RuleBase:RU004468, ECO:0000313|EMBL:EHB03242.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1927
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003473936"
FT TRANSMEM 1883..1903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 1273
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
FT ACT_SITE 1749
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ SEQUENCE 1927 AA; 218273 MW; 2026D7B78DC4749C CRC64;
MEPSWKVALI ILLSFSCQGS DWESDRNFIS AAGPLTSDLL HNLSHLLGNQ SSHFVAGYKD
IYTCHQPLPS FIPEYFKSLH NSKITHYKVF LSWAQLLPSG SSRNPDGKTL QCYRQLLEAL
KTAQLQPMVI LHHQTLPTST LQRSRVFADL FADYATFAFH SFGDLVGIWF TFSDLKGTMM
GLSHKESRAS HLQTLTDAHR KVYEIYHAKY ASQGGKLSVV LPSDDLLEAL LEPSVSALAK
DSVDFLSLDL SYECQSEASL PEKLNKLQSI EPKVKVFIFT LKLQDCPSTK KNPARMLFSL
FEAINKDHVC TIGFDVNEFL SCSSSKKSMS CSLTDSLALQ SDQQQDRDTA GGPLSPDSAY
WRVWEAFANQ SRTERDAFLQ DVFPEDFLWG VSTGAFNVEG GWAEGGRGAS IWDQYGLNGT
RGQATPEVAS DSYHKSASDV ALLRGLRAQV YKFSISWSRI FPTGHRSSPN LQGVTYYNKL
IDTLLGSHIK PMVTLFHWDL PQALQDLGGW QNENVVDAFL DYAAFCFSTF GDRVKLWVTF
HEPWVVSYAG YGTGQHAPGI SDPGVASFKV AHLILKAHAR TWHHYNSHHR AQQQGSVGIV
LNSDWAEPLS PEQPEDLTAS ERFLHFMLGW FAHPIFVDGG YPPTMKAQIQ QLNKQCSGPV
AQLPEFTRAE KQLIKGSADF LGLSHYTSRL IRKGQQDTCV PSYENIGGFS QHVDPAWPQT
ASPWIRVVPW GIRRLLQFVS MEYTRGKVPI YLAGNGMPIG ENNSLFDDSS RVAYFNQYIN
EVLKAVKEDS VDVRSYIARS LIDGFEGPSG YSQRFGLHHV NFSDSSKPRT PRKSACFFTT
IIEKNGFTTK VVKRSLPSKV AEFPSKIRTF NFPSEVPSKA KVVWEKFSNQ PKFERDFFYH
GTFRDDFLWG VSSSAYQIEG AWDAEGKGPS IWDNFTHTPG NAVKDNATGD IACDSYNNLD
ADLNILRALK VKAYRFSMAW SRIFPDGTNS FINRAGVEYY NRLISGLVAS NILPMVTLFH
WDLPQALQDI GGWENPSLIE LFDSYADFCF QTFGDRVKFW MTFNEPAIQA WNGYGLGNFP
PNVKDPGWGP YRIGHAVIKA HARVYHTYDE KYRQQQQGVI SLSLSTHWAE PKSPGVPRDV
EAADRMLQFS LGWFAHPIFR NGDYPDVMKW KVGNRSELQH LATSRLPSFT EEEKRYIRGT
ADVFCFNTYS SRLVQHTTPP LNPPSYQYDQ EITEEEDPSW VATAINRAAP WGIRRLLNWI
KEEYGDVPIY ITENGVGLTS GALQDTDRIF YHKTYINEAL KAYRLDGIDL RGYSAWSLMD
NFEWLEGYTV KFGLYHVDFE DVNRPRTARA SASYYTEVIT NNGMPMPKED EFLYGEFPKG
FIWSAASAAY QIEGAWRTDG KGLSIWDMYS HTPLRIENDD TGDVACDSYH KIAEDVVVLQ
NLGVSHYRFS ISWTRILPDG TTKYINEMGL NYYVRLIDAL LAANIEPQVT LYHWDLPQAL
QDVGGWENET IVQRFKEYAD VLFRRLGDKV KFWITLNEPF VIACHGYGTG VSAPGISSRP
GTAPYTAGHN LIKAHAEAWH LYNDVYRASQ GGMISITISS DWAEPRDPSN QEDVEAARRY
VQFMGGWFAH PIFKNGDYPD VMKTRIRDRS LAAGLNKSRL PEFTQSEKRR INGTYDYFGF
NHYTTVLAYN LNYASVYSSF DADRGVMSIA DQSWPVSGSF WLKMTPFGFR RILNWLKEEY
NNPPIYVTEN GVSQRGEVDL NDTARIYYLR SYINEALKAV QDKVDLRGYT VWTVMDNFEW
ATGFTERFGL HYVNRTDPSL PRIPKESAKF YASVVRCNGF PDPAAGPHPC LQQPEDAEPT
TIPVREEVPF LGLKLGITEA QTALYVLFSL MLLGVCVLAF LSYKYCKFSK KEKTQPSQQE
LSRISSF
//
