ID G5B2H0_HETGA Unreviewed; 1832 AA.
AC G5B2H0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Myotubularin-related protein 5 {ECO:0000313|EMBL:EHB03481.1};
DE Flags: Fragment;
GN ORFNames=GW7_00582 {ECO:0000313|EMBL:EHB03481.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03481.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03481.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; JH168132; EHB03481.1; -; Genomic_DNA.
DR STRING; 10181.G5B2H0; -.
DR eggNOG; KOG1090; Eukaryota.
DR eggNOG; KOG2080; Eukaryota.
DR InParanoid; G5B2H0; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 1..425
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1059..1561
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1726..1830
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1570..1594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1687..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB03481.1"
SQ SEQUENCE 1832 AA; 204480 MW; 0AE849A1831283FC CRC64;
PLSSGSGEGQ GQILQRFPEK DWEDNPFPQG IELFCQPSGW QVCPERNPPT FFVAVLTDIN
SERHYCACLT FWEPVEPKQE AVGTKGTVER EEEADERGQG QLSPATPVQP GQLYAPKTLV
LVSRLDHTEV FRNSLGLIYT IHVEGLNVCL ENVIGNLLTC TVPLAGGSQR TISLGAGDRQ
VIQTPLADSL PVSRCSVALL FRQLGITNVL SLFCAALTEH KVLFLSRSYQ RLADACRGLL
ALLFPLRYSF TYVPILPAQL LEVLSTPTPF IIGVNAAFQA ETQELLDVIV ADLDGGTVAV
PECVHIPPLP EPLQSQTHSV LSMVLDPELE LADLAFPPPT VSTSSLKMQD KELRAVFLRL
FAQLLQGYRW CLHIVRIHPE PVIRFHKAAF LGQRGLVEDD FLMKVLEGMA FAGFVSERGV
PYRPTDLFDE LVAHEVARMR ADENHPQRVL RHVQELAEQL YKNENPYPAV SMHKVQRPAA
KMQGAPPAVR AERRSTVPSG SPMTAIAERS SGPHINSARR LEVVRSCISC VFEGKMLEAK
KLLPAVLRAL KGRAARRCLA QELHVHVQQN RAVLDHQQFD FVVRMMNCCL QDCTSLDEHG
IAAALLPLVT AFCRKLSPGV TQFAYSCVQE HVVWSTPQFW EAMFYGDVQT HIRALYLEPP
EDQSPSQEAG EVPAQEDERS ALDVASEQRR LWPTLSREKQ QELVQKEEST VFSQAIHYAN
RMSYLLLPLD SSKSRLLRER AGLGDLESAS NSLVTNRLGG PWVGLGXFIN RFVDKVCTES
GVTSDHLKGL HVMVPDIVQM HVETLEAVHR ESKRLPPIQK PKLLRPRLLP GEECVLDGLR
VYLLPDGREG ATGGSGGGPA LLPAEGAVFL ATYRVVFTGM PTDPLVGEQV VVRSFPLAAL
TKEKRISVQT PMDQLLQDGL QLRSCTFQLL KMAFDEEVGS DSAELFRKQL HKLRYPADIR
GTFAFTLGSA YTPSKPARTA KDKGPSFRTL SRNLVKNAKK TIGRQYVTRK RYNPPGWEQH
GQPPTEDQED EISVSEESEP STLTPSSALK PSDRMTMSSL VERACCRDYQ RLGLGTLSSS
LSRAKSEPFR ISPVNRMYAI CRSYPGLLIV PQSIQDNALQ RVSRCYRQNR FPVVCWRSGR
SKAVLLRSGG LHGKGVVGLF KAQNAPSPGQ SQADSSSLEQ EKYLQAVVSS MPRYADASGR
NTLSGFSSAH MGSHVPSPRA RVTTLSNPMA ASASRRTAPR GKWGSVRASG RSSGLSTDVG
SRLASRDGLS APQANGAPPD PGFLRPHRAA LYIIGDKAQL KGVRQDPLQQ WELVPIEVFE
SRQVKASFKK LLKACVPGCP ATEPGPASFL RSLEDSEWLI QIHRLLQISV LVVELLDAGS
SVLVSLEDGW DVTTQVVSLV QLLSDPFYRT LEGFRLLVEK EWLSFGHRFS HRGAHTLAGQ
SSGFTPVFLQ FLDCVYQVHL QFPMEFEFSQ FYLKFLGYHH ASRRFRTFLL DSDYERIELG
LLYEEKGERK GQLVCRSVWE YVDRLSKRTP VFYNYMYAPE DTEVLRPYSN VSNLKVWDFY
TEETLAEGPP YDWELAQGPP EPPEEERPDG SAHQSRRRVV WPCYDSRPRV QPDALSRLLQ
ELQRLETELG RPSERWKDTW DRVKAAQRLE VRPDGRGTPS SLLVSSVPHH RRSLGVYLQE
GPMGSTLSLS LDSDQSSGSA TSXARQAARR STSTLYSQFQ TAESENRSYE GTLYKKGAFM
KPWKARWFVL DKTKHQLRYY DHRVDTECKG VIDLAEVEAV GPGTPTMGAP KTVDEKAFFD
VKTTRRVYNF CAQDVPSAQQ WVDRIQSCLS DA
//
