ID G5B2P5_HETGA Unreviewed; 1137 AA.
AC G5B2P5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Unc-13-like protein C {ECO:0000313|EMBL:EHB03556.1};
DE Flags: Fragment;
GN ORFNames=GW7_05490 {ECO:0000313|EMBL:EHB03556.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03556.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03556.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH168142; EHB03556.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B2P5; -.
DR STRING; 10181.G5B2P5; -.
DR eggNOG; KOG1011; Eukaryota.
DR InParanoid; G5B2P5; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:UniProt.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF2; PROTEIN UNC-13 HOMOLOG C; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 21..71
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 127..251
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 561..704
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 809..951
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 967..1092
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB03556.1"
SQ SEQUENCE 1137 AA; 129604 MW; 0660FD56B1002CA9 CRC64;
KMHVFRKTLQ ALVYPMSCTT PHAFEVWTAT TPTYCYECEG LLWGIARQGV RCLECGVKCH
EKCQDLLNAD CLQRAAEKSS KHGTEDKTQT IITAMKERMK IREKNKPEVF EVIQEMFQIP
KEDFVQYRKA AKQSVLDGTS KWSAKITITV VSAQGLQAKD KTGSSDPYVT VQVGKNKKRT
KTIFGNLNPV WDEKFYFECH NSTDRIKVRV WDEDDDIKSR VKQHFKKESD DFLGQTIVEV
RTLSGEMDVW YNLEKRTDKS AVSGAIRLKI NVEIKGEEKV APYHIQYTCL HENLFHYLTE
VKSSGSVKIP EVKGDEAWKV FFDDASQEIV DEFAMRYGIE SIYQAMTHFS CLSSKYMCPG
VPAIMSTLLA NINAFYAHTT VSTNVQVSAS DRFAATNFGR EKFIKLLDQL HNSLRIDLSK
YRENFPASSS ERLQDLKSTV DLLTSITFFR MKVLELPSPP RASMVVKDCV RACLDSTYKY
IFDNCHELYS QLTDPSKQQD IPQEDQGPTS RNLDFWPQLI TLMVTIIDED KAAYTPALNQ
FPQELNMGKI SAEIMWTLFA LDMKYALEEH QKQRLCKSTD YMNLHFKVKW FYNEYVHELP
AFKDAVPEYS LWFEPFVMQW LDENEDVSME FLHGALGRDK KDGFQQTSDH ALFSCSVVDV
FAQLNQSFEI IRKLECPNPE ALSHLMRRFA KTISKVLVQY AAIVSSDFSS YCDKENVPCV
LMNNIQQLRV QLEKMFESMG GKLDPEASTI LKELQVRLSG VLDRLSVIYG ESFQLVIEEC
VKQMSFELHQ MRANGSTASS RSSATLDAGI VLRPLMELLD KTLSLSAKIC EKTVLKRVLK
ELWKLVLNKI EKQIVLPPLT DQTGPPMIFI AAKDLGQLSK LKEHLSREDA RGLTPRQCAV
LEEVLATVKQ YFHAGGNGLK KNFLEKSPDL QSLRYALSLY TQTTDALIKK FIDTQTSQSR
SSKDAVGQIS VHVDIAATPG TGEHKVTVKV IAINDLHWQT TAMFRPFVEV CMLGPNLGDK
KRKQGTKTKS NTWSPKYNET FQFTLSKESQ PAAYELHLAV KDYCFAREDR VIGMTVIQLQ
TIEEKGSHGA WYPLLRSVSM DETGLTILRI LSQRTGDDVA KEFVRLKSET RVTEESA
//
