ID G5B450_HETGA Unreviewed; 1253 AA.
AC G5B450;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Laminin subunit gamma-2 {ECO:0000313|EMBL:EHB04061.1};
GN ORFNames=GW7_02155 {ECO:0000313|EMBL:EHB04061.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04061.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB04061.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; JH168392; EHB04061.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B450; -.
DR STRING; 10181.G5B450; -.
DR eggNOG; KOG1836; Eukaryota.
DR InParanoid; G5B450; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 6.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF313; LAMININ SUBUNIT GAMMA-2; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 6.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00281; LamB; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 3.
DR PROSITE; PS51115; LAMININ_IVA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1253
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003473991"
FT DOMAIN 147..193
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 202..249
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 276..443
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 579..634
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 709..764
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 874..901
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 147..159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 167..176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 220..229
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 603..612
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1253 AA; 138205 MW; C3B5C9FDB1D4B77A CRC64;
MPVLWLSCLC LSFLLPAAGA TSRREDEEDD TQRGMLTTML SQLAIGELCS SKHNSFVEWK
IEAPKSDCLD QRHTVRNSAM FQLPDECYQV CDCNGKSNQC IFEEELHWRT GNGLRCLNCK
DNTDGLHCER CREGFYWHQD RDHCLPCNCH SKGSLSPQCD NSGRCSCKPG VTGDKCDQCL
PGFHMLTDAG CTQDQRRLAF KCDCDPAGLA GPCDSGHCVC KPAVTGERCD RCRPGYYHLD
AGNPEGCTQC FCYGHSASCR SSTDYSVHKI TSTFQRDVDG WKAVQRNGSS AKLHWSQRYR
NVYTSARRDP VFFVAPARFL GNQQVSYGQS LSFDYRVDRG GRHSSAHDVI LEGAGLQITA
PLIPRGKILP CGITKTYTFR LNEHPSSTWS PQLSYFEYRR LLRNLTALRI RATYGEYSTG
YIDNVTLISA RPVSGAPAPW VEHCICPVGY KGQFCQDCAS GYKRDSARLG PFGTCIPCNC
QGGGACDPDT GDCYSGDENP EIECADCPIG FYNDPHDPRS CKPCPCHNGF SCSVMPETEE
VVCNNCPTGV TGARCELCAD GYFGDPFGER GPVRPCQPCQ CNNNVDPSAS GNCDGLTGRC
LKCIHNTAGF NCDQCKAGYF GDPLAPSRAN KCQACNCNPV GSQSGECRSD GSCVCKPGFG
GLNCEHGALS NCPACYGQVN TQMAQFMEQL QGLEALISKA QGGGGLIPNS ELEGRLQQAE
QALQDILREA QISEDASRSL SLQLAKARSQ ENSYQNRLGD LKKTVERVQA LGSQYQNRVQ
DTRRLITQMR LSLAENEAAL RNSDIPPSDQ YVGPNGFKSL AQEAMRLADS HVESASNMEQ
LVKKTEDYSK QALLLAGKAL SEAVGSEITD NHAIQGLMGK LEKTKSLAQQ LTREATQTDT
EADKSYQHSL RLLDSVSQLQ GVNDQTFQVE AKRIQKKADS LSSLVTRHTD EFKLVRSNLG
NWGKETQQLL QDGKKERQKS DQLLSRASLA KSRAQEALSM GNATFYEVEN ILKNLREFDL
QVEDRKAEAE EAMKRLSYIS QKVADASDKM EQAEGSLGSA AADAQRAKNA AREALEISGK
IEQEIGSLNL EANVTADGAL AMEKGLATLK SEMREVEGEL ARKELEFDTD MDTMQMVITE
ARRVDTRAKN AGVTIQDTLK SLDSILHLTD QPGSVDEERL ALLEQELFQT KTRINSQLRP
LMSELEERAR RQRGHLHFLE MSIDGILADV KNLENIRDNL PPGCYNTQTL EQQ
//
