ID G5B8I0_HETGA Unreviewed; 1151 AA.
AC G5B8I0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=ADAMTS-like protein 2 {ECO:0000313|EMBL:EHB05591.1};
GN ORFNames=GW7_14322 {ECO:0000313|EMBL:EHB05591.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05591.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05591.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH169003; EHB05591.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B8I0; -.
DR STRING; 10181.G5B8I0; -.
DR eggNOG; KOG3538; Eukaryota.
DR InParanoid; G5B8I0; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF147; ADAMTS-LIKE PROTEIN 2; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 4.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00209; TSP1; 7.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1151
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474201"
FT DOMAIN 1105..1143
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 224..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 124192 MW; B0CC6DDB5EA50F66 CRC64;
MRFPRGTWAV AFLPGLLLSA PGPCSSSQQA AGLAWLGSRG AERVKVCASP AGGGRGSGPV
GRMLFEVGEG GGQAAGGRRE AELHVPGLRS LSLAAHLVLA PALGGQPAEA RPAGSGLVVT
VALIPRMDGG WQCSQWAWSL LAMAVVAGGA ANTELSDNSP TSNSLEGGAD ATAYWWGEWT
KWTACSRSCG GGVMSQERHC LQQRKQQGSI SLVALAGDST LDSPPVPSIL DLPHPRRKSV
PGAGNRTCSG TSKSYQLCSL KECPPDRRSF REEQCVSFNS RVFDGRTYQW KPLYPDDYVH
ISSKPCDLHC TTVDGQRQLM GSARDGTSCK LTDLRGVCVS GKCEPIGCDG VLFSTHTLDK
CGVCQGDGSS CTHVTGNYRK GNAPLGYSLV THIPAGARDI QIVERKKSAD VLALADEAGF
YFFNGNYKVD SPKNFNIAGT VVKYRRPMDI YETGIEYIVA QGPTNQGLNV MVWNQNGKSP
SITFEYTLLQ SPPTHHRPSL YYSFSEPPSA STSAESQELL GFLQRNASLH SPASSEQLGL
DNRLFGPQDP DMELGLLRGP ETNEVCEPAG SGVCQGPSRA KGFRDRNATG MARMRDKDDQ
EADVHLTSQE LLSANAISDQ LLGAGSDSEE FALNETGNSI FAQGAPRSPT TESLYVDYEA
GAGVAAYLLN GSYLELSSDR VTNASSEAPF PNASASLPSL AGNRTHKART RPKARKPGVS
PADMYRWKLS SHEPCSATCT TGVMSTYALC VRYDGVEVDD SYCDALTRPE PVHEFCAGRE
CQPRWETSSW SECSRTCGEG YQARIVRCWK MLSPGFDSSV YSDLCEATEA VRPEERKTCR
NPACGPQWEM SEWSECTARC GERSVVTRDI RCSEDEELCD PSTRPVGEKN CTGPPCDRQW
TVSDWGPVLA EAASAGGVGG ARVPRKLRFS LCVFSIDRVI SCSGSCGQGR TIRHVYCKTS
DGRVVPESQC QAETKPLAIH PCGDRNCPAH WLAQDWERCN TTCGRGVKKR LVLCMELTNG
KPQTRSGPEC GLARKPPVES TCFERPCFRW YTSPWSECTK TCGVGVRMRD VKCYQGTDVV
RGCDPLVKPV GRQACDLQPC PTEPPDDSCQ DQPGTNCALA IKVNLCGHWY YSKACCRSCR
PPAPSRAAAG P
//
