ID G5BDT0_HETGA Unreviewed; 695 AA.
AC G5BDT0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Vitrin {ECO:0000313|EMBL:EHB07441.1};
GN ORFNames=GW7_13658 {ECO:0000313|EMBL:EHB07441.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB07441.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB07441.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH169772; EHB07441.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BDT0; -.
DR STRING; 10181.G5BDT0; -.
DR eggNOG; KOG1216; Eukaryota.
DR InParanoid; G5BDT0; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01472; vWA_collagen; 2.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF23; VITRIN; 1.
DR Pfam; PF03815; LCCL; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00603; LCCL; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..146
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 310..495
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 512..685
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 695 AA; 76633 MW; 8B5E3D30EA81D2D2 CRC64;
MIKENIRLRR EKHLGERILI TFYNFYFLHA VLLVTGIHSN KEMAKKSKRP KFTVPQINCD
VQAGKIINPE FIVKCPAGCQ DPKYHVYGTS VYASYSSLCG AAVHSGVLDN SGGKILVQKV
AGQSGYRGSY SNGVQSLSLP RWRESFIVSE SKPKKGVTYP SALIYSSSKT PAAKAGKYET
TKAYQKPSVP ETTAQPVALM QVLANLETEA THITLPKPSL LVASDTSSPR PQPMGHRSWE
MVCKLEPVSA HRLVTGYPSG TNNFWSSLSS VLLGLPRTID DEYQGFVPKE ELSTQALEPV
SLGDPNCKVD LSFLIDGSSS IGKRRFRIQK QFLADVAQAV DIGPSGPLMG VVQYGDNPAT
HFNLKTHTNS RDLKAAIEKI TLRGGLSNAG RAISFVTKNF FSKANGNRGG APNVAVVLLD
GWPTDKVEET SRLARESGIN IFFITIEAAL ENEKQYVVEP NFASKAVCRT NGYYSFSVQS
WFGLRKTVQP LVKRICDTDR LACSKTCFNS ADIGFIIDGS SSVGTGNFRT VLQFVANLSK
EFEISDTDTR IGAVQYTYEQ RLEFGFDKYH TKADILNAIK SVGYWSGGTS TGAAIHYALE
QLFKKSKPNK RKLMILITDG KSYDDVRIPA MAAHQRGVIT YAIGVAWAAQ EELDIIATHP
ARDHSFFVDE FDNLYTSVPK IIRNICTEFN SQPRN
//
