ID G5BNB7_HETGA Unreviewed; 318 AA.
AC G5BNB7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier {ECO:0000256|ARBA:ARBA00040836};
DE AltName: Full=Solute carrier family 25 member 19 {ECO:0000256|ARBA:ARBA00041879};
GN ORFNames=GW7_04471 {ECO:0000313|EMBL:EHB10778.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10778.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10778.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC diphosphate into mitochondria. It is not clear if the antiporter
CC activity is affected by the membrane potential or by the proton
CC electrochemical gradient. {ECO:0000256|ARBA:ARBA00037549}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=thiamine diphosphate(in) + thiamine phosphate(out) = thiamine
CC diphosphate(out) + thiamine phosphate(in); Xref=Rhea:RHEA:73383,
CC ChEBI:CHEBI:37575, ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00035968};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; JH171126; EHB10778.1; -; Genomic_DNA.
DR RefSeq; XP_004860714.1; XM_004860657.2.
DR RefSeq; XP_012933634.1; XM_013078180.1.
DR AlphaFoldDB; G5BNB7; -.
DR STRING; 10181.G5BNB7; -.
DR Ensembl; ENSHGLT00000085361; ENSHGLP00000041017; ENSHGLG00000005191.
DR Ensembl; ENSHGLT00100068608; ENSHGLP00100055142; ENSHGLG00100002377.
DR GeneID; 101715161; -.
DR KEGG; hgl:101715161; -.
DR CTD; 60386; -.
DR eggNOG; KOG0752; Eukaryota.
DR InParanoid; G5BNB7; -.
DR OMA; MYVCYGA; -.
DR OrthoDB; 261981at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:Ensembl.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF59; MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 13..106
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 116..202
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 214..309
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 318 AA; 35240 MW; CBAE89E2A9586DFE CRC64;
MVGYDPKADD RNNSKFEVAV AGSVSGLVTR VLISPLDVIK IRFQLQIERL SHGDPKAKYH
GILQASRQIF REEGPTAFWK GHIPAQLLSV GYGAVQFLSF QLLTELVHRA NVYDTHEFSA
HFVCGGLSAC AATLTIHPVD VLRTRFAAQG EPRVYKTLQD AVVTMYRTEG PLVFYKGLAP
TLIAIFPYAG LQFSCYRSLK HAYDWAIPAD GKQTGNLKNL LCGSGAGIIS KTLTYPLDLF
KKRLQVGGFE HARAAFGQVR SYTGLLDCIK QVLREEGGRG FFKGLSPSLL KAAISTGFVF
FWYELFCNLF HCMKKADS
//
